Résultat de recherche

03 - Juillet - 2020

The Spatial Heterogeneity of the Gut Limits Predation and Fosters Coexistence of Bacteria and Bacteriophages (Équipe Seksik - Sokol) Marta Lourenco, Lorenzo Chaffringeon, Quentin Lamy-Besnier, Thierry Pedron, Pascal Campagne, Claudia Eberl, Marion Berard, Barbel Stecher, Laurent Debarbieux, Luisa De Sordi

Cell Host Microbe. 2020;28(3):390-401 e5 The ecological dynamics underlying the coexistence between antagonistic populations of bacteria and their viruses, bacteriophages (phages), in the...

19 - Septembre - 2020

The Gut Microbiota at the Service of Immunometabolism (Équipe Seksik - Sokol) Chloé Michaudel, Harry Sokol

Cell Metab. 2020;32(4):514-23 The gut microbiota is implicated in immune system functions. Regulation of the metabolic processes occurring in immune cells is crucial for the maintenance of...

CHOSSEGROS Manon

02 - Décembre - 2020

Tryptophan Metabolism as a Pharmacological Target (Équipe Seksik - Sokol) Morgane Modoux Nathalie Rolhion Sridhar Mani Harry Sokol

Trends Pharmacol Sci. 2020 L-Tryptophan is an essential amino acid required for protein synthesis. It undergoes an extensive and complex metabolism along several pathways, resulting in many...

17 - Décembre - 2020

Anti-Inflammatory Effects of Analogues of N-Acyl Homoserine Lactones on Eukaryotic Cells (Équipe Seksik - Sokol) Agathe Peyrottes, Garance Coquant, Loic Brot, Dominique Rainteau, Philippe Seksik, Jean-Pierre Grill, Jean-Maurice Mallet

Int J Mol Sci. 2020;21(24) BACKGROUND : Since acyl-homoserine lactone (AHL) profiling has been described in the gut of healthy subjects and patients with inflammatory bowel disease (IBD),...

CHOUCHÈNE Mouna

04 - Mai - 2020

AhR activation defends gut barrier integrity against damage occurring in obesity (Équipe Seksik - Sokol) Barbara G Postal, Sara Ghezzal, Doriane Aguanno, Sebastien Andre, Kevin Garbin, Laurent Genser, Edith Brot-Laroche, Christine Poitou, Hedi Soula, Armelle Leturque, Karine Clement, Veronique Carriere

Mol Metab. 2020;39:101007 OBJECTIVE : Obesity is characterized by systemic and low-grade tissue inflammation. In the intestine, alteration of the intestinal barrier and accumulation of...

CHWETZOFF Serge

30 - Novembre - 2019

Contribution of adipocyte precursors in the phenotypic specificity of intra-articular adipose tissues in knee osteoarthritis patients (Équipe Berenbaum) Florent Eymard, Audrey Pigenet, Cindy Rose, Anouchka Bories, Charles-Henri Flouzat-Lachaniette, Francis Berenbaum, Xavier Chevalier, Xavier Houard, Geoffroy Nourissat

Arthritis Res Ther. 2019;21(1):252 Background : Intra-articular adipose tissues (IAATs) are involved in osteoarthritis (OA) pathophysiology. We hypothesize that mesenchymal cells residing...

18 - Octobre - 2019

Danger signals and inflammaging in osteoarthritis (Équipe Berenbaum) Marion Millerand, Francis Berenbaum, Claire Jacques

Clin Exp Rheumatol. 2019;37 Suppl 120(5):48-56 Osteoarthritis (OA) is the most com- mon age-related chronic and disabling joint disease. Long considered to be a “wear and tear”...

11 - Janvier - 2019

Impairment of glyoxalase-1, an advanced glycation end-product detoxifying enzyme, induced by inflammation in age-related osteoarthritis (Équipe Berenbaum) Sabine Trellu, Alice Courties, Stéphane Jaisson, Laëtitia Gorisse, Philippe Gillery, Saadia Kerdine-Römer, Carlos Vaamonde-Garcia, Xavier Houard, François-Paul Ekhirch, Alain Sautet, Bertrand Friguet, Claire Jacques, Francis Berenbaum, Jérémie Sellam

Arthritis Res Ther. 2019;21(1):18 Background : Accumulation of advanced glycation end-products (AGEs) is involved in age-related osteoarthritis (OA). Glyoxalase (Glo)-1 is the main enzyme...

03 - Novembre - 2019

Respiratory Epithelial Cells Can Remember Infection: A Proof of Concept Study (Équipe Corvol) Jeanne Bigot, Loic Guillot, Juliette Guitard, Manon Ruffin, Harriet Corvol, Michel Chignard, Hennequin Christophe, Viviane Balloy

J Infect Dis. 2019 Human bronchial epithelial cells play a key role in airway immune homeostasis. We hypothesized that these sentinel cells can remember a previous contact with pathogen...

CLOSSET Lara

01 - Janvier - 2019

Glucocorticoid-induced insulin resistance is related to macrophage visceral adipose tissue infiltration (Équipe Fève) Thi Thu Huong Do, Marie Garcia, Héloïse Dalle, Guillaume Dorothée, Marthe Moldes, BrunoFève, MarionBuyse

J Steroid Biochem Mol Biol. 2019;185:150-62 Insulin resistance is frequently present in patients with glucocorticoid (GC) excess (Cushing's syndrome) or treated with high doses of GCs....

01 - Janvier - 2019

Adaptive beta-Cell Neogenesis in the Adult Mouse in Response to Glucocorticoid-Induced Insulin Resistance (Équipe Fève) Emilie Courty, Adrien Besseiche, Thi Thu Huong Do, Alexandrine Liboz, Fatima Mohamed Aguid, Evans Quilichini, Melissa Buscato, Pierre Gourdy, Jean-François Gautier, Jean-Pierre Riveline, Cécile Haumaitre, Marion Buyse, Bruno Fève, Ghislaine Guillemain, Bertrand Blondeau

Diabetes. 2019;68(1):95-108 Both type 1 and type 2 diabetes are characterized by deficient insulin secretion and decreased beta-cell mass. Thus, regenerative strategies to increase...

01 - Février - 2019

Adipocyte Glucocorticoid Receptor Deficiency Promotes Adipose Tissue Expandability and Improves the Metabolic Profile Under Corticosterone Exposure (Équipe Fève) Héloïse Dalle, Marie Garcia, Bénédicte Antoine, Vanessa Boehm, Thi Thu Huong Do, Marion Buyse, Tatiana Ledent, Antonin Lamazière, Christophe Magnan, Catherine Postic, Raphaël George Denis, Serge Luquet, Bruno Fève, Marthe Moldes

Diabetes. 2019;68(2):305-17 Widely used for their anti-inflammatory and immunosuppressive properties, glucocorticoids are nonetheless responsible for the development of diabetes and...

COLASSE Sabrina

COLLE Raphaël

01 - Mai - 2019

Impact of HIV/simian immunodeficiency virus infection and viral proteins on adipose tissue fibrosis and adipogenesis (Équipe Fève) Jennifer Gorwood, Christine Bourgeois, Matthieu Mantecon, Michael Atlan, Valérie Pourcher, Guillaume Pourcher, Roger Le Grand, Delphine Desjardins, Bruno Fève, Olivier Lambotte, Jacqueline Capeau, Véronique Béréziat, Claire Lagathu

AIDS. 2019;33(6):953-64 Objective : HIV-infected patients receiving antiretroviral treatment (ART) often present adipose tissue accumulation and/or redistribution. adipose tissue has been...

27 - Juin - 2019

A mutation inactivating the distal SF1 binding site on the human anti-Mullerian hormone promoter causes persistent Mullerian duct syndrome (Équipe Fève) Helena F. Schteingart, Jean-YvesPicard, Clara Valeri, Ian Marshall, Dominique Treton, Nathalie di Clemente, Rodolfo A. Rey, Nathalie Josso

Hum Mol Genet. 2019;28(19):3211-8 The persistent Mullerian duct syndrome (PMDS) is a 46,XY disorder of sexual development characterized by the persistence of Mullerian duct derivatives,...

COLLURA Ada

19 - Décembre - 2019

Breast-Associated Adipocytes Secretome Induce Fatty Acid Uptake and Invasiveness in Breast Cancer Cells via CD36 Independently of Body Mass Index, Menopausal Status and Mammary Density (Équipes Larsen/Sabbah – Fève – Seksik/Sokol) Maurice Zaoui, Mehdi Morel, Nathalie Ferrand, Soraya Fellahi, Jean-Philippe Bastard, Antonin Lamaziere, Annette Kragh Larsen, Véronique Béréziat, Michael Atlan, Michèle Sabbah

Cancers (Basel). 2019;11(12) Breast adiposity is correlated with body mass index, menopausal status and mammary density. We here wish to establish how these factors influence the cross-talk...

15 - Avril - 2019

Ci-hox12 tail gradient precedes and participates in the control of the apoptotic-dependent tail regression during Ciona larva metamorphosis (Équipe Prunier) G. Krasoveca, K. Robinea, E. Quéinnec, A. Karaiskoub, J.P. Chambon

Dev Biol. 2019;448(2):237-46 At the onset of the Ciona intestinalis metamorphosis, the first event is tail regression characterized, by a contraction, an apoptotic wave and Primordial Germ...

CORNEAU Aurélien

11 - Février - 2019

SERPINA1 Z allele is associated with cystic fibrosis liver disease (Équipe Corvol) Pierre-Yves Boëlle, Dominique Debray, Loic Guillot, Harriet Corvol & on behalf of the French CF Modifier Gene Study Investigators

Genetics in Medicine 2019 Purpose : The SERPINA1 Z allele is associated with cystic fibrosis (CF)-related liver disease (CFLD), a common manifestation in patients with CF. We estimated...

24 - Septembre - 2019

Genetic contribution of ABCC2 to Dubin-Johnson syndrome and inherited cholestatic disorders (Équipe Housset / Fève) Christophe Corpechot, Véronique Barbu, Olivier Chazouillères, Pierre Broue, Muriel Girard, Bertrand Roquelaure, Yves Chrétien, Catherine Dong, Olivier Lascols, Chantal Housset, Isabelle Jéru

Liver Int. 2019 Background and aims : The ABCC2 gene is implicated in Dubin-Johnson syndrome (DJS), a rare autosomal recessive liver disorder. The primary aim of this study was to determine...

CORPECHOT Christophe

05 - Avril - 2019

Atmospheric pressure plasma jets applied to cancerology: correlating electrical configuration with in vivo toxicity and therapeutic efficiency (Équipe Housset) F Judée, J Vaquero, S Guégan, L Fouassier, T Dufour

Journal of Physics D: Applied Physics. 2019;52(24) Two atmospheric pressure plasma jet (APPJ) devices—a plasma gun and a plasma Tesla jet—are compared in terms of safety and...

19 - Avril - 2019

Fungi participate in the dysbiosis of gut microbiota in patients with primary sclerosing cholangitis (Équipe Housset & Seksik-Sokol) Sara Lemoinne, Astrid Kemgang, Karima Ben Belkacem, Marjolène Straube, Sarah Jegou, Christophe Corpechot, Saint-Antoine I. B. D. Network, Olivier Chazouilleres, Chantal Housset, Harry Sokol

Gut. 2019 Objective : Patients with primary sclerosing cholangitis (PSC) were previously shown to display a bacterial gut dysbiosis but fungal microbiota has never been examined in these...

CORVOL Harriet

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