Résultat de recherche

10 - Juillet - 2020

Arsenic trioxide induces regulatory functions of plasmacytoid dendritic cells through interferon- alpha inhibition (Équipe Mohty ) Yishan Ye, Laure Ricard, Lama Siblany, Nicolas Stocker, Fréderic De Vassoigne, Eolia Brissot, Baptiste Lamarthee, Arsène Mekinian, Mohamad Mohty, Béatrice Gaugler, Florent Malard

Acta Pharm Sin B. 2020;10(6):1061-72 Arsenic trioxide (As2O3) is recently found to have therapeutic potential in systemic sclerosis (SSc), a life-threatening multi-system fibrosing...

CAMBRIEL Amélie

CAMUS Claire

04 - Juin - 2020

Plasmacytoid dendritic cell biology and its role in immune-mediated diseases (Équipe Mohty) Yishan Ye, Béatrice Gaugler, Mohamad Mohty, Florent Malard

Clin Transl Immunology. 2020;9(5):e1139 Plasmacytoid dendritic cells (pDCs) are a unique subset of dendritic cells specialised in secreting high levels of type I interferons. pDCs play a...

CAMUS Marine

15 - Décembre - 2020

Insights from the genetic characterization of central precocious puberty associated with multiple anomalies (Équipe Netchine) Ana Pinheiro Machado Canton, Ana Cristina Victorino Krepischi, Luciana Ribeiro Montenegro, Silvia Costa, Carla Rosenberg, Virginie Steunou, Marie-Laure Sobrier, Lucas Santana, Rachel Sayuri Honjo, Chong Ae Kim, Francis de Zegher, Jan Idkowiak, Lorna C. Gilligan, Wiebke Arlt, Mariana Ferreira de Assis Funari, Alexander Augusto de Lima Jorge, Berenice Bilharinho Mendonca, Irene Netchine, Vinicius Nahime Brito, Ana Claudia Latronico

Hum Reprod. 2021 Jan 25;36(2):506-518 STUDY QUESTION : Is there an (epi)genetic basis in patients with central precocious puberty (CPP) associated with multiple anomalies that unmasks...

CANLORBE Geoffroy

22 - Septembre - 2020

Changes in circulating miRNA19a-3p precede insulin resistance programmed by intra-uterine growth retardation in mice (Équipe Netchine / Fève / Seksik - Sokol) Sarah Saget, Rong Cong, Lyvianne Decourtye, Marie-Laure Endale, Laetitia Martinerie, Clemence Girardet, Claire Perret, Maud Clemessy, Patricia Leneuve, Laetitia Dinard, Mohand Badreddine Oumoussa, Dominique Farabos, Antonin Lamaziere, Marc Lombes, Marthe Moldes, Bruno Feve, David Tregouet, Le Yves Bouc, Laurent Kappeler

Mol Metab. 2020;42:101083 OBJECTIVE : Individuals born with intrauterine growth retardation (IUGR) are more prone to cardio-metabolic diseases as adults, and environmental changes during...

CAPEAU Jacqueline

23 - Septembre - 2020

Derivation and Validation of a Predictive Score for Disease Worsening in Patients with COVID-19 (Équipe Larsen-Sabbah) Grigoris T. Gerotziafas, Theodoros N. Sergentanis, Guillaume Voiriot, Ludovic Lassel, Chryssa Papageorgiou, Alexandre Elabbadi, Matthieu Turpin, Patrick Vandreden, Loula Papageorgiou, Theodora Psaltopoulou, Evangelos Terpos, Meletios-Athanasios Dimopoulos, Antoine Parrot, Jacques Cadranel, Gilles Pialoux, Muriel Fartoukh, Ismail Elalamy

Thromb Haemost. 2020 The prospective observational cohort study COMPASS-COVID-19 aimed to develop a risk assessment model for early identification of hospitalized COVID-19 patients at risk...

CAPEL Emilie

14 - Septembre - 2020

Guidance for the Management of Patients with Vascular Disease or Cardiovascular Risk Factors and COVID-19: Position Paper from VAS-European Independent Foundation in Angiology/Vascular Medicine (Équipe Larsen-Sabbah) Grigoris T. Gerotziafas, Mariella Catalano, Mary-Paula Colgan, Zsolt Pecsvarady, Jean Claude Wautrecht, Bahare Fazeli, Dan-Mircea Olinic, Katalin Farkas, Ismail Elalamy, Anna Falanga, Jawed Fareed, Chryssa Papageorgiou, Rosella S. Arellano, Petros Agathagelou, Darco Antic, Luciana Auad, Ljiljana Banfic, John R. Bartolomew, Bela Benczur, Melissa B. Bernardo, Francesco Boccardo, Renate Cifkova, Benilde Cosmi, Sergio De Marchi, Evangelos Dimakakos, Meletios A. Dimopoulos, Gabriel Dimitrov, Isabelle

Thromb Haemost. 2020 COVID-19 is also manifested with hypercoagulability, pulmonary intravascular coagulation, microangiopathy, and venous thromboembolism (VTE) or arterial thrombosis....

01 - Juin - 2020

Broad-spectrum antiviral activity of naproxen: from Influenza A to SARS-CoV-2 Coronavirus (Équipe Sabbah) Olivier Terrier, Sébastien Dilly, Andrés Pizzorno, Julien Henri, Francis Berenbaum, Bruno Lina, Bruno Fève, Frédéric Adnet, Michèle Sabbah, Manuel Rosa-Calatrava, Vincent Maréchal, Anny Slama Schwok

bioRxiv 2020 There is an urgent need for specific antiviral drugs directed against SARS-CoV-2 both to prevent the most severe forms of COVID-19 and to reduce viral excretion and subsequent...

27 - Octobre - 2020

The intestinal quorum sensing 3-oxo-C12:2 Acyl homoserine lactone limits cytokine-induced tight junction disruption (Équipe Seksik - Sokol) Doriane Aguanno, Garance Coquant, Barbara G Postal, Céline Osinski, Margaux Wieckowski, Daniel Stockholm, Jean-Pierre Grill, Véronique Carriere, Philippe Seksik, Sophie Thenet

Tissue Barriers. 2020;8(4):1832877 The intestine is home to the largest microbiota community of the human body and strictly regulates its barrier function. Tight junctions (TJ) are major...

05 - Décembre - 2020

Gut microbiota-derived metabolites as central regulators in metabolic disorders (Équipe Seksik - Sokol) Allison Agus, Karine Clement, Harry Sokol

Gut. 2020 Metabolic disorders represent a growing worldwide health challenge due to their dramatically increasing prevalence. The gut microbiota is a crucial actor that can interact with...

CARRIERE Véronique

29 - Septembre - 2020

Impact of N-Acyl-Homoserine Lactones, Quorum Sensing Molecules, on Gut Immunity (Équipe Seksik - Sokol) Garance Coquant, Jean-Pierre Grill, Philippe Seksik

Front Immunol. 2020;11:1827 Among numerous molecules found in the gut ecosystem, quorum sensing (QS) molecules represent an overlooked part that warrants highlighting. QS relies on the...

30 - Août - 2020

Linking Strain Engraftment in Fecal Microbiota Transplantation With Maintenance of Remission in Crohn's Disease (Équipe Seksik - Sokol) Lingjia Kong, Jason Lloyd-Price, Tommi Vatanen, Philippe Seksik, Laurent Beaugerie, Tabassome Simon, Hera Vlamakis, Harry Sokol, Xavier J Ramnik

Gastroenterology. 2020;159(6):2193-202 e5 BACKGROUND & AIMS : Crohn's disease (CD) is a chronic gastrointestinal disease resulting from the dysfunctional interplay between genetic...

CERVERA Pascale

23 - Octobre - 2020

Aryl hydrocarbon receptor ligand production by the gut microbiota is decreased in celiac disease leading to intestinal inflammation (Équipe Seksik - Sokol) Bruno Lamas, Leticia Hernandez-Galan, Heather J Galipeau, Marco Constante, Alexandra Clarizio, Jennifer Jury, Natalia M Breyner, Alberto Caminero, Gaston Rueda, Christina LHayes, Justin LMcCarville, Miriam Bermudez Brito, Julien Planchais, Nathalie Rolhion, Joseph A Murray, Philippe Langella, Linda M P Loonen, Jerry M Wells, Premysl Bercik, Harry Sokol, Elena F Verdu

Sci Transl Med. 2020;12(566) Metabolism of tryptophan by the gut microbiota into derivatives that activate the aryl hydrocarbon receptor (AhR) contributes to intestinal homeostasis. Many...

20 - Septembre - 2020

Jejunum: The understudied meeting place of dietary lipids and the microbiota (Équipe Seksik - Sokol ) Ingrid Lema, Joao Ricardo Araujo, Nathalie Rolhion, Sylvie Demignot

Biochimie. 2020;178:124-36 Although the jejunum is the main intestinal compartment responsible for lipid digestion and absorption, most of the studies assessing the impact of dietary lipids...

03 - Juillet - 2020

The Spatial Heterogeneity of the Gut Limits Predation and Fosters Coexistence of Bacteria and Bacteriophages (Équipe Seksik - Sokol) Marta Lourenco, Lorenzo Chaffringeon, Quentin Lamy-Besnier, Thierry Pedron, Pascal Campagne, Claudia Eberl, Marion Berard, Barbel Stecher, Laurent Debarbieux, Luisa De Sordi

Cell Host Microbe. 2020;28(3):390-401 e5 The ecological dynamics underlying the coexistence between antagonistic populations of bacteria and their viruses, bacteriophages (phages), in the...

CHABBERT-BUFFET Nathalie

19 - Septembre - 2020

The Gut Microbiota at the Service of Immunometabolism (Équipe Seksik - Sokol) Chloé Michaudel, Harry Sokol

Cell Metab. 2020;32(4):514-23 The gut microbiota is implicated in immune system functions. Regulation of the metabolic processes occurring in immune cells is crucial for the maintenance of...

CHAIGNEAU Thomas

02 - Décembre - 2020

Tryptophan Metabolism as a Pharmacological Target (Équipe Seksik - Sokol) Morgane Modoux Nathalie Rolhion Sridhar Mani Harry Sokol

Trends Pharmacol Sci. 2020 L-Tryptophan is an essential amino acid required for protein synthesis. It undergoes an extensive and complex metabolism along several pathways, resulting in many...

17 - Décembre - 2020

Anti-Inflammatory Effects of Analogues of N-Acyl Homoserine Lactones on Eukaryotic Cells (Équipe Seksik - Sokol) Agathe Peyrottes, Garance Coquant, Loic Brot, Dominique Rainteau, Philippe Seksik, Jean-Pierre Grill, Jean-Maurice Mallet

Int J Mol Sci. 2020;21(24) BACKGROUND : Since acyl-homoserine lactone (AHL) profiling has been described in the gut of healthy subjects and patients with inflammatory bowel disease (IBD),...

04 - Mai - 2020

AhR activation defends gut barrier integrity against damage occurring in obesity (Équipe Seksik - Sokol) Barbara G Postal, Sara Ghezzal, Doriane Aguanno, Sebastien Andre, Kevin Garbin, Laurent Genser, Edith Brot-Laroche, Christine Poitou, Hedi Soula, Armelle Leturque, Karine Clement, Veronique Carriere

Mol Metab. 2020;39:101007 OBJECTIVE : Obesity is characterized by systemic and low-grade tissue inflammation. In the intestine, alteration of the intestinal barrier and accumulation of...

CHAPEL Alain

30 - Novembre - 2019

Contribution of adipocyte precursors in the phenotypic specificity of intra-articular adipose tissues in knee osteoarthritis patients (Équipe Berenbaum) Florent Eymard, Audrey Pigenet, Cindy Rose, Anouchka Bories, Charles-Henri Flouzat-Lachaniette, Francis Berenbaum, Xavier Chevalier, Xavier Houard, Geoffroy Nourissat

Arthritis Res Ther. 2019;21(1):252 Background : Intra-articular adipose tissues (IAATs) are involved in osteoarthritis (OA) pathophysiology. We hypothesize that mesenchymal cells residing...

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