Résultat de recherche

01 - Décembre - 2018

Diet-Induced Dysbiosis and Genetic Background Synergize With Cystic Fibrosis Transmembrane Conductance Regulator Deficiency to Promote Cholangiopathy in Mice (Équipes Housset - Seksik/Sokol) Dominique Debray, Haquima El Mourabit, Fatiha Merabtene, Loïc Brot, Damien Ulveling, Yves Chrétien, Dominique Rainteau, Ivan Moszer, Dominique Wendum, Harry Sokol, Chantal Housset

Hepatol Commun. 2018;2(12):1533-49 The most typical expression of cystic fibrosis (CF)-related liver disease is a cholangiopathy that can progress to cirrhosis. We aimed to determine the...

COULOMB Aurore

08 - Octobre - 2018

Endoplasmic reticulum stress induces inverse regulations of major functions in portal myofibroblasts during liver fibrosis progression (Équipe Housset) Emilien Loeuillard, Haquima El Mourabit, Lin Lei, Sara Lemoinne, Chantal Housset, Axelle Cadoret

Biophys Acta Mol Basis Dis. 2018;1864(12):3688-96 Portal myofibroblasts (PMF) form a sub-population of highly proliferative and proangiogenic liver myofibroblasts that derive from portal...

COURTIES Alice

19 - Décembre - 2018

LCR1 and LCR2, two multi-analyte blood tests to assess liver cancer risk in patients without or with cirrhosis (Équipe Housset) Thierry Poynard, Valentina Peta, Olivier Deckmyn, Mona Munteanu, Joseph Moussalli, Yen Ngo, Marika Rudler, Pascal Lebray, Raluca Pais, Luminita Bonyhay, Frederic Charlotte, Vincent Thibault, Laetitia Fartoux, Olivier Lucidarme, Daniel Eyraud, Olivier Scatton, Eric Savier, Marc Antoine Valantin, An Ngo, Fabienne Drane, Olivier Rosmorduc, Françoise Imbert‐Bismut, Chantal Housset, Dominique Thabut, Vlad Ratziu, the HECAM‐FibroFrance Group

Aliment Pharmacol Ther. 2019;49(3):308-20 Background : No blood test has been shown to be effective in the prediction of primary liver cancer in patients without cirrhosis. AIM: To...

03 - Mai - 2018

The IGF2/IR/IGF1R Pathway in Tumor Cells and Myofibroblasts Mediates Resistance to EGFR Inhibition in Cholangiocarcinoma (Équipe Housset) Javier Vaquero, Cindy Lobe, Sylvana Tahraoui, Audrey Clapéron, Martine Mergey, Fatiha Merabtene, Dominique Wendum, Cédric Coulouarn, Chantal Housset, Christèle Desbois-Mouthon, Françoise Praz, Laura Fouassier

Clin Cancer Res. 2018;24(17):4282-96 Purpose : Cholangiocarcinoma (CCA) is a desmoplastic tumor of the biliary tree in which epidermal growth factor receptor (EGFR) is overexpressed and...

COUVERT Philippe

10 - Août - 2017

Genetic disruption of the oncogenic HMGA2–PLAG1–IGF2 pathway causes fetal growth restriction (Équipe Netchine) Walid Abi Habib, Frédéric Brioude, Thomas Edouard, James T. Bennett, Anne Lienhardt-Roussie, Frédérique Tixier, Jennifer Salem, Tony Yuen, Salah Azzi, Yves Le Bouc, Madeleine D. Harbison, Irène Netchine

Genet Med. 2018;20(2):250-8 Purpose : Fetal growth is a complex process involving maternal, placental and fetal factors. The etiology of fetal growth retardation remains unknown in many...

29 - Janvier - 2018

Expert consensus document: Clinical and molecular diagnosis, screening and management of Beckwith-Wiedemann syndrome: an international consensus statement. (Équipe Netchine) F. Brioude, J.M. Kalish, A.Mussa, A.C. Foster, J. Bliek, G. Battista Ferrero, S.E. Boonen, T. Cole, R. Baker, M. Bertoletti, G. Cocchi, C. Coze, M. De Pellegrin, K. Hussain, A. Ibrahim, M.D. Kilby, M. Krajewska-Walasek, C.P. Kratz, E.J. Ladusans, P.Lapunzina, Y.Le Bouc, S.M. Maas, F.Macdonald, K.Õunap, L.Peruzzi, S.Rossignol, S.Russo, C.Shipster, A.Skórka, K. Tatton-Brown, J. Tenorio, C. Tortora, K. Grønskov, I. Netchine, R. C. Hennekam, D. Prawitt, Z. Tümer, T. Eggermann, D.J.G. Mackay, A. Ricc

Nat Rev Endocrinol. 2018;14(4):229-49 Beckwith–Wiedemann syndrome (BWS), a human genomic imprinting disorder, is characterized by phenotypic variability that might include overgrowth,...

CREUSOT Laura

11 - Avril - 2018

Chromosome 14q32.2 Imprinted Region Disruption as an Alternative Molecular Diagnosis of Silver-Russell Syndrome (Équipe Netchine) S. Geoffron, W. Abi Habib, S. Chantot-Bastaraud, B. Dubern, V. Steunou, S. Azzi, A. Afenjar, T. Busa, A. Pinheiro Canton, C. Chalouhi, M.-N. Dufourg, B. Esteva, M. Fradin, D. Geneviève, S. Heide, B. Isidor, A. Linglart, F. Morice Picard, C. Naud-Saudreau, I. Oliver Petit, N. Philip, C. Pienkowski, M. Rio, S. Rossignol, M. Tauber, J. Thevenon, T.A. Vu-Hong, M.D. Harbison, J. Salem, F. Brioude, I. Netchine, E. Giabicani

J Clin Endocrinol Metab. 2018;103(7):2436-46 Context : Silver-Russell syndrome (SRS) (mainly secondary to 11p15 molecular disruption) and Temple syndrome (TS) (secondary to 14q32.2...

01 - Août - 2018

Diagnosis and management of postnatal fetal growth restriction (Équipe Netchine) Eloïse Giabicani, Aurélie Pham, Frédéric Brioude, Delphine Mitanchez, Irène Netchine

Best Pract Res Clin Endocrinol Metab. 2018;32(4):523-34 Fetal growth restriction (FGR) can result from multiple causes, such as genetic, epigenetic, environment, hormonal regulation, or...

09 - Décembre - 2017

Chromosomal rearrangements in the 11p15 imprinted region: 17 new 11p15.5 duplications with associated phenotypes and putative functional consequences (Équipe Netchine) Solveig Heide, Sandra Chantot-Bastaraud, Boris Keren, Madeleine D Harbison, Salah Azzi, Sylvie Rossignol, Caroline Michot, Marilyn Lackmy-Port Lys, Bénédicte Demeer, Claudine Heinrichs, Ron S Newfield, Pierre Sarda, Lionel Van Maldergem, Véronique Trifard, Eloise Giabicani, Jean-Pierre Siffroi, Yves Le Bouc, Irène Netchine, Frédéric Brioude

Med Genet. 2018;55(3):205-13 Background : The 11p15 region contains two clusters of imprinted genes. Opposite genetic and epigenetic anomalies of this region result in two distinct growth...

DALISSIER Arnaud

16 - Février - 2018

The NDPK/NME superfamily: state of the art (Équipe Prunier) Mathieu Boissan, Uwe Schlattner, Marie-Lise Lacombe

Lab Invest. 2018;98(2):164-74 Nucleoside diphosphate kinases (NDPK) are nucleotide metabolism enzymes encoded by NME genes (also called NM23). Given the fact that not all NME-encoded...

DANNE Camille

18 - Juin - 2018

Twist1 activation in muscle progenitor cells causes muscle loss akin to cancer cachexia (Équipe Prunier) Parash Parajuli, Santosh Kumar, Audrey Loumaye, Purba Singh, Sailaja Eragamreddy, Thien Ly Nguyen, Seval Ozkan, Mohammed S. Razzaque, Céline Prunier, Jean-Paul Thissen, Azeddine Atfi

Dev Cell. 2018;45(6):712-25 e6 Cancer cachexia is characterized by extreme skeletal muscle loss that results in high morbidity and mortality. The incidence of cachexia varies among tumor...

DE GRAMONT Aimery

01 - Mars - 2018

The extracellular domain of Her2 in serum as a biomarker of breast cancer (Équipe Prunier) Alexandre Perrier, Joseph Gligorov, Guillaume Lefèvre, Mathieu Boissan

Lab Invest. 2018;98(6):696-707 Breast cancer is a major health problem worldwide. In ~15% of breast cancers, the epidermal growth factor receptor HER2, a transmembrane protein, is...

DE SORDI Luisa

29 - Mai - 2018

Modeling of Aniridia-Related Keratopathy by CRISPR/Cas9 Genome Editing of Human Limbal Epithelial Cells and Rescue by Recombinant PAX6 Protein (Équipe Prunier) Lauriane N. Roux, Isabelle Petit, Romain Domart, Jean-Paul Concordet, Jieqiong Qu, Huiqing Zhou, Alain Joliot, Olivier Ferrigno, Daniel Aberdam

Stem Cells. 2018;36(9):1421-9 Heterozygous PAX6 gene mutations leading to haploinsufficiency are the main cause of congenital aniridia, a rare and progressive panocular disease...

01 - Février - 2018

Radiotherapy-Activated Cancer-Associated Fibroblasts Promote Tumor Progression through Paracrine IGF1R Activation (Équipe Prunier) Joke Tommelein, Elly De Vlieghere, Laurine Verset, Élodie Melsens, Justine Leenders, Bénédicte Descamps, Annelies Debucquoy, Christian Vanhove, Patrick Pauwels, Christian P.Gespach, Anne Vral, De Astrid Boeck, Karin Haustermans, de Pascal Tullio, Wim Ceelen, Pieter Demetter, Tom Boterberg, Marc Bracke, Olivier De Wever

Cancer Res. 2018;78(3):659-70 Preoperative radiotherapy (RT) is a mainstay in the management of rectal cancer, a tumor characterized by desmoplastic stroma containing cancer-associated...

10 - Avril - 2018

Influence of Progenitor-Derived Regeneration Markers on Hepatitis C Virus-Related Cirrhosis Outcome (ANRS CO12 CirVir Cohort) (Équipe Prunier) Dominique Wendum, Richard Layese, Nathalie Ganne-Carrie, Valérie Bourcier, Fatiha Merabtene, Carole Cagnot, Emmanuel Sauce, Nathalie Barget, Pierre Bedossa, Benoît Terris, Janick Selves, Paulette Bioulac-Sage, Nathalie Sturm, Christophe Sattonnet, Pierre Nahon, Françoise Roudot-Thoraval, Marianne Ziol

Hepatology. 2018;68(4):1534-48 Progenitor-derived regeneration gives rise to the aberrant expression of biliary markers such as cytokeratin 7 (K7) and epithelial cell adhesion molecule...

23 - Mars - 2018

The orphan GPR50 receptor promotes constitutive TGFbeta receptor signaling and protects against cancer development (Équipe Prunier) Stefanie Wojciech, Raise Ahmad, Zakia Belaid-Choucair, Anne-Sophie Journe, Sarah Gallet, Julie Dam, Avais Daulat, Delphine Ndiaye-Lobry, Olivier Lahuna, Angeliki Karamitri, Jean-Luc Guillaume, Marcio Do Cruzeiro, François Guillonneau, Anastasia Saade, Nathalie Clément, Thomas Courivaud, Nawel Kaabi, Kenjiro Tadagaki, Philippe Delagrange, Vincent Prévot, Olivier Hermine, Céline Prunier, Ralf Jockers

Nat Commun. 2018;9(1):1216 Transforming growth factor-beta (TGFbeta) signaling is initiated by the type I, II TGFbeta receptor (TbetaRI/TbetaRII) complex. Here we report the formation of an...

DE VASSOIGNE Frédéric

13 - Juin - 2018

Gut Microbiota Regulation of Tryptophan Metabolism in Health and Disease (Équipe Seksik/Sokol) Allison Agus, Julien Planchais, Harry Sokol

Cell Host Microbe. 2018;23(6):716-24 The gut microbiota is a crucial actor in human physiology. Many of these effects are mediated by metabolites that are either produced by the microbes or...

DEBOST Henry

01 - Novembre - 2018

Bile acid homeostasis and intestinal dysbiosis in alcoholic hepatitis (Équipe Seksik/Sokol) Dragos Ciocan, Cosmin Sebastian Voican, Laura Wrzosek, Cindy Hugot, Dominique Rainteau, Lydie Humbert, Anne-Marie Cassard, Gabriel Perlemuter

Aliment Pharmacol Ther. 2018;48(9):961-74 Background : Intestinal microbiota plays an important role in bile acid homeostasis. Aim : To study the structure of the intestinal microbiota...

22 - Octobre - 2018

Mixed signals from the cell's antennae: primary cilia in cancer (Équipe Seksik/Sokol) Thibaut Eguether, Michael Hahne

EMBO Rep. 2018;19(11) Primary cilia (PC) are antenna-like organelles that protrude from most mammalian cells. They are essential for the regulation of several signaling pathways such as...

DELAUNAY Jean-Louis

5
9
10
11
12
13
14
15
19

Hôpital St-Antoine

Bâtiment Kourilsky
34 rue Crozatier
75012 PARIS

Sorbonne Université
27 rue Chaligny
75012 PARIS

+(33)1 49 28 46 00

cm.crsa@inserm.fr

Se rendre à Saint-Antoine

Ce site utilise des cookies et vous donne le contrôle sur ce que vous souhaitez activer Tout accepter Personnaliser