Résultat de recherche

15 - Mars - 2020

Inhibition of receptor-interacting protein kinase 1 improves experimental non-alcoholic fatty liver disease (Équipe Housset) Amine Majdi, Lynda Aoudjehane, Vlad Ratziu, Tawhidul Islam, Marta B. Afonso, Filomena Conti, Taïeb Mestiri, Marie Lagouge, Fabienne Foufelle, Florine Ballenghien1, Tatiana Ledent, Marthe Moldes, Axelle Cadoret, Laura Fouassier, Jean-Louis Delaunay, Tounsia Aït-Slimane, Gilles Courtois, Bruno Fève, Olivier Scatton, Carina Prip-Buus, Cecília M.P. Rodrigues, Chantal Housset, Jérémie Gautheron

J Hepatol. 2019 [Epub ahead of print] Background & Aims : In non-alcoholic fatty liver disease (NAFLD), hepatocytes can undergo necroptosis: a regulated form of necrotic cell death...

28 - Avril - 2020

Photothermal Depletion of Cancer-Associated Fibroblasts Normalizes Tumor Stiffness in Desmoplastic Cholangiocarcinoma (Équipe Housset) Alba Nicolás-Boluda, Javier Vaquero, Gautier Laurent, Gilles Renault, Rana Bazzi, Emmanuel Donnadieu, Stéphane Roux, Laura Fouassier, Florence Gazeau

ACS Nano. 2020;14(5):5738-53 Physical oncology recognizes tissue stiffness mediated by activation of cancer-associated fibroblasts (CAF) and extracellular matrix remodeling as an active...

CHIGNARD Nicolas

23 - Mai - 2020

Cold-Atmospheric Plasma Induces Tumor Cell Death in Preclinical In Vivo and In Vitro Models of Human Cholangiocarcinoma (Équipe Housset) Javier Vaquero, Florian Judee, Marie Vallette, Henri Decauchy, Ander Arbelaiz, Lynda Aoudjehane, Olivier Scatton, Ester Gonzalez-Sanchez, Fatiha Merabtene, Jérémy Augustin, Chantal Housset, Thierry Dufour, Laura Fouassier

Cancers (Basel). 2020;12(5) Through the last decade, cold atmospheric plasma (CAP) has emerged as an innovative therapeutic option for cancer treatment. Recently, we have set up a...

11 - Décembre - 2020

Introduction to host microbiome symbiosis in health and disease (Équipe Mohty) Florent Malard, Joel Dore, Beatrice Gaugler, Mohamad Mohty

Mucosal Immunol. 2020 Humans share a core intestinal microbiome and yet human microbiome differs by genes, species, enterotypes (ecology), and gene count (microbial diversity). Achievement...

CHORFI Louise

03 - Octobre - 2020

High-dose post-transplant cyclophosphamide impairs gammadelta T-cell reconstitution after haploidentical haematopoietic stem cell transplantation using low-dose antithymocyte globulin and peripheral blood stem cell graft (Équipe Mohty) Nicolas Stocker, Béatrice Gaugler, Myriam Labopin, Agathe Farge, Yishan Ye, Laure Ricard, Eolia Brissot, Remy Dulery, Simona Sestili, Giorgia Battipaglia, Clemence Mediavilla, Annalisa Paviglianiti, Anne Banet, Van De Zoe Wyngaert, Tounes Ledraa, Mohamad Mohty, Florent Malard,

Clin Transl Immunology. 2020;9(9):e1171 OBJECTIVES : Haploidentical haematopoietic cell transplantation (Haplo-HCT) using peripheral blood stem cell (PBSC) grafts and post-transplant...

10 - Juillet - 2020

Arsenic trioxide induces regulatory functions of plasmacytoid dendritic cells through interferon- alpha inhibition (Équipe Mohty ) Yishan Ye, Laure Ricard, Lama Siblany, Nicolas Stocker, Fréderic De Vassoigne, Eolia Brissot, Baptiste Lamarthee, Arsène Mekinian, Mohamad Mohty, Béatrice Gaugler, Florent Malard

Acta Pharm Sin B. 2020;10(6):1061-72 Arsenic trioxide (As2O3) is recently found to have therapeutic potential in systemic sclerosis (SSc), a life-threatening multi-system fibrosing...

CHOSSEGROS Manon

04 - Juin - 2020

Plasmacytoid dendritic cell biology and its role in immune-mediated diseases (Équipe Mohty) Yishan Ye, Béatrice Gaugler, Mohamad Mohty, Florent Malard

Clin Transl Immunology. 2020;9(5):e1139 Plasmacytoid dendritic cells (pDCs) are a unique subset of dendritic cells specialised in secreting high levels of type I interferons. pDCs play a...

15 - Décembre - 2020

Insights from the genetic characterization of central precocious puberty associated with multiple anomalies (Équipe Netchine) Ana Pinheiro Machado Canton, Ana Cristina Victorino Krepischi, Luciana Ribeiro Montenegro, Silvia Costa, Carla Rosenberg, Virginie Steunou, Marie-Laure Sobrier, Lucas Santana, Rachel Sayuri Honjo, Chong Ae Kim, Francis de Zegher, Jan Idkowiak, Lorna C. Gilligan, Wiebke Arlt, Mariana Ferreira de Assis Funari, Alexander Augusto de Lima Jorge, Berenice Bilharinho Mendonca, Irene Netchine, Vinicius Nahime Brito, Ana Claudia Latronico

Hum Reprod. 2021 Jan 25;36(2):506-518 STUDY QUESTION : Is there an (epi)genetic basis in patients with central precocious puberty (CPP) associated with multiple anomalies that unmasks...

CHOUCHÈNE Mouna

22 - Septembre - 2020

Changes in circulating miRNA19a-3p precede insulin resistance programmed by intra-uterine growth retardation in mice (Équipe Netchine / Fève / Seksik - Sokol) Sarah Saget, Rong Cong, Lyvianne Decourtye, Marie-Laure Endale, Laetitia Martinerie, Clemence Girardet, Claire Perret, Maud Clemessy, Patricia Leneuve, Laetitia Dinard, Mohand Badreddine Oumoussa, Dominique Farabos, Antonin Lamaziere, Marc Lombes, Marthe Moldes, Bruno Feve, David Tregouet, Le Yves Bouc, Laurent Kappeler

Mol Metab. 2020;42:101083 OBJECTIVE : Individuals born with intrauterine growth retardation (IUGR) are more prone to cardio-metabolic diseases as adults, and environmental changes during...

CHWETZOFF Serge

23 - Septembre - 2020

Derivation and Validation of a Predictive Score for Disease Worsening in Patients with COVID-19 (Équipe Larsen-Sabbah) Grigoris T. Gerotziafas, Theodoros N. Sergentanis, Guillaume Voiriot, Ludovic Lassel, Chryssa Papageorgiou, Alexandre Elabbadi, Matthieu Turpin, Patrick Vandreden, Loula Papageorgiou, Theodora Psaltopoulou, Evangelos Terpos, Meletios-Athanasios Dimopoulos, Antoine Parrot, Jacques Cadranel, Gilles Pialoux, Muriel Fartoukh, Ismail Elalamy

Thromb Haemost. 2020 The prospective observational cohort study COMPASS-COVID-19 aimed to develop a risk assessment model for early identification of hospitalized COVID-19 patients at risk...

14 - Septembre - 2020

Guidance for the Management of Patients with Vascular Disease or Cardiovascular Risk Factors and COVID-19: Position Paper from VAS-European Independent Foundation in Angiology/Vascular Medicine (Équipe Larsen-Sabbah) Grigoris T. Gerotziafas, Mariella Catalano, Mary-Paula Colgan, Zsolt Pecsvarady, Jean Claude Wautrecht, Bahare Fazeli, Dan-Mircea Olinic, Katalin Farkas, Ismail Elalamy, Anna Falanga, Jawed Fareed, Chryssa Papageorgiou, Rosella S. Arellano, Petros Agathagelou, Darco Antic, Luciana Auad, Ljiljana Banfic, John R. Bartolomew, Bela Benczur, Melissa B. Bernardo, Francesco Boccardo, Renate Cifkova, Benilde Cosmi, Sergio De Marchi, Evangelos Dimakakos, Meletios A. Dimopoulos, Gabriel Dimitrov, Isabelle

Thromb Haemost. 2020 COVID-19 is also manifested with hypercoagulability, pulmonary intravascular coagulation, microangiopathy, and venous thromboembolism (VTE) or arterial thrombosis....

01 - Juin - 2020

Broad-spectrum antiviral activity of naproxen: from Influenza A to SARS-CoV-2 Coronavirus (Équipe Sabbah) Olivier Terrier, Sébastien Dilly, Andrés Pizzorno, Julien Henri, Francis Berenbaum, Bruno Lina, Bruno Fève, Frédéric Adnet, Michèle Sabbah, Manuel Rosa-Calatrava, Vincent Maréchal, Anny Slama Schwok

bioRxiv 2020 There is an urgent need for specific antiviral drugs directed against SARS-CoV-2 both to prevent the most severe forms of COVID-19 and to reduce viral excretion and subsequent...

27 - Octobre - 2020

The intestinal quorum sensing 3-oxo-C12:2 Acyl homoserine lactone limits cytokine-induced tight junction disruption (Équipe Seksik - Sokol) Doriane Aguanno, Garance Coquant, Barbara G Postal, Céline Osinski, Margaux Wieckowski, Daniel Stockholm, Jean-Pierre Grill, Véronique Carriere, Philippe Seksik, Sophie Thenet

Tissue Barriers. 2020;8(4):1832877 The intestine is home to the largest microbiota community of the human body and strictly regulates its barrier function. Tight junctions (TJ) are major...

CLOSSET Lara

05 - Décembre - 2020

Gut microbiota-derived metabolites as central regulators in metabolic disorders (Équipe Seksik - Sokol) Allison Agus, Karine Clement, Harry Sokol

Gut. 2020 Metabolic disorders represent a growing worldwide health challenge due to their dramatically increasing prevalence. The gut microbiota is a crucial actor that can interact with...

29 - Septembre - 2020

Impact of N-Acyl-Homoserine Lactones, Quorum Sensing Molecules, on Gut Immunity (Équipe Seksik - Sokol) Garance Coquant, Jean-Pierre Grill, Philippe Seksik

Front Immunol. 2020;11:1827 Among numerous molecules found in the gut ecosystem, quorum sensing (QS) molecules represent an overlooked part that warrants highlighting. QS relies on the...

30 - Août - 2020

Linking Strain Engraftment in Fecal Microbiota Transplantation With Maintenance of Remission in Crohn's Disease (Équipe Seksik - Sokol) Lingjia Kong, Jason Lloyd-Price, Tommi Vatanen, Philippe Seksik, Laurent Beaugerie, Tabassome Simon, Hera Vlamakis, Harry Sokol, Xavier J Ramnik

Gastroenterology. 2020;159(6):2193-202 e5 BACKGROUND & AIMS : Crohn's disease (CD) is a chronic gastrointestinal disease resulting from the dysfunctional interplay between genetic...

COLLE Raphaël

23 - Octobre - 2020

Aryl hydrocarbon receptor ligand production by the gut microbiota is decreased in celiac disease leading to intestinal inflammation (Équipe Seksik - Sokol) Bruno Lamas, Leticia Hernandez-Galan, Heather J Galipeau, Marco Constante, Alexandra Clarizio, Jennifer Jury, Natalia M Breyner, Alberto Caminero, Gaston Rueda, Christina LHayes, Justin LMcCarville, Miriam Bermudez Brito, Julien Planchais, Nathalie Rolhion, Joseph A Murray, Philippe Langella, Linda M P Loonen, Jerry M Wells, Premysl Bercik, Harry Sokol, Elena F Verdu

Sci Transl Med. 2020;12(566) Metabolism of tryptophan by the gut microbiota into derivatives that activate the aryl hydrocarbon receptor (AhR) contributes to intestinal homeostasis. Many...

COLLURA Ada

20 - Septembre - 2020

Jejunum: The understudied meeting place of dietary lipids and the microbiota (Équipe Seksik - Sokol ) Ingrid Lema, Joao Ricardo Araujo, Nathalie Rolhion, Sylvie Demignot

Biochimie. 2020;178:124-36 Although the jejunum is the main intestinal compartment responsible for lipid digestion and absorption, most of the studies assessing the impact of dietary lipids...

03 - Juillet - 2020

The Spatial Heterogeneity of the Gut Limits Predation and Fosters Coexistence of Bacteria and Bacteriophages (Équipe Seksik - Sokol) Marta Lourenco, Lorenzo Chaffringeon, Quentin Lamy-Besnier, Thierry Pedron, Pascal Campagne, Claudia Eberl, Marion Berard, Barbel Stecher, Laurent Debarbieux, Luisa De Sordi

Cell Host Microbe. 2020;28(3):390-401 e5 The ecological dynamics underlying the coexistence between antagonistic populations of bacteria and their viruses, bacteriophages (phages), in the...

COLSON Flavie

19 - Septembre - 2020

The Gut Microbiota at the Service of Immunometabolism (Équipe Seksik - Sokol) Chloé Michaudel, Harry Sokol

Cell Metab. 2020;32(4):514-23 The gut microbiota is implicated in immune system functions. Regulation of the metabolic processes occurring in immune cells is crucial for the maintenance of...

02 - Décembre - 2020

Tryptophan Metabolism as a Pharmacological Target (Équipe Seksik - Sokol) Morgane Modoux Nathalie Rolhion Sridhar Mani Harry Sokol

Trends Pharmacol Sci. 2020 L-Tryptophan is an essential amino acid required for protein synthesis. It undergoes an extensive and complex metabolism along several pathways, resulting in many...

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