Résultat de recherche

14 - Juillet - 2020

Identification of TGFbeta signatures in six murine models mimicking different osteoarthritis clinical phenotypes (Équipe Berenbaum) M. Maumus, D. Noël, H.K. Ea, D. Moulin, M. Ruiz, E. Hay, X. Houard, D. Cleret, M. Cohen-Solal, C. Jacques, J.-Y. Jouzeau, M.-H. Lafage-Proust, P. Reboul, J. Sellam, C. Vinatier, F. Rannou, C. Jorgensen, J. Guicheux a, F. Berenbaum

Osteoarthritis Cartilage. 2020;28(10):1373-84 OBJECTIVE : TGFbeta is a key player in cartilage homeostasis and OA pathology. However, few data are available on the role of TGFbeta...

CARRIERE Véronique

17 - Mars - 2020

Activation of innate immunity by 14-3-3 epsilon, a new potential alarmin in osteoarthritis (Équipe Berenbaum) M. Millerand, L. Sudre, M. Nefla, F. Pène, C. Rousseau, A. Pons, A. Ravat, G. André-Leroux, S. Akira, T. Satoh, F. Berenbaum, C. Jacques

Osteoarthritis Cartilage. 2020;28(5):646-57 OBJECTIVE : The innate immune system plays a central role in osteoarthritis (OA). We identified 14-3-3epsilon as a novel mediator that guides...

01 - Mai - 2020

Atypical presentation of COVID-19 in young infants (Équipe Corvol) Nadia Nathan, Blandine Prévost, Harriet Corvol

Lancet. 2020;395(10235):1481 As of April 27, 2020, more than two million people worldwide have been diagnosed with coronavirus disease 2019 (COVID-19), with Europe being one of the current...

CERVERA Pascale

20 - Août - 2020

Flagellin from Pseudomonas aeruginosa increases the expression of the SARS-CoV2 entry protease TMPRSS2 in airway epithelial cells (Équipe Corvol) Manon Ruffin, Jeanne Bigot, Claire Calmel, Harriet Corvol, Viviane Balloy, Loïc Guillot

BioRxiv The major challenge of the COVID-19 health crisis is to identify the factors of susceptibility to SARS-Cov2 in order to adapt the recommendations to the populations and to reduce...

24 - Juin - 2020

Innate Immune Signaling and Proteolytic Pathways in the Resolution or Exacerbation of SARS-CoV-2 in Covid-19: Key Therapeutic Targets? (Équipe Corvol) Jean-Michel Sallenave, Loïc Guillot

Front Immunol. 2020;11:1229 COVID-19 is caused by the Severe Acute Respiratory Syndrome (SARS) coronavirus (Cov)-2, an enveloped virus with a positive-polarity, single-stranded RNA genome....

CHABBERT-BUFFET Nathalie

31 - Juillet - 2020

Tissue damage from neutrophil-induced oxidative stress in COVID-19 (Équipe Dorothée) Mireille Laforge, Carole Elbim, Corinne Frere, Miryana Hemadi, Charbel Massaad, Philippe Nuss, Jean-Jacques Benoliel, Chrystel Becker

Nat Rev Immunol. 2020;20(9):515-6 The high neutrophil to lymphocyte ratio observed in critically ill patients with COVID-19 is associated with excessive levels of reactive oxygen species...

26 - Février - 2020

Novel defatting strategies reduce lipid accumulation in primary human culture models of liver steatosis (Équipe Housset) Lynda Aoudjehane, Jérémie Gautheron, Wilfried Le Goff, Claire Goumard, Julia Gilaizeau, Chan Sonavine Nget, Éric Savier, Muhammad Atif, Philippe Lesnik, Romain Morichon, Yves Chrétien, Yvon Calmus, Olivier Scatton, Chantal Housset, Filomena Conti

Dis Model Mech. 2020;13(4) Normothermic perfusion provides a means to rescue steatotic liver grafts, including by pharmacological defatting. In this study, we tested the potential of new...

CHAIGNEAU Thomas

15 - Mars - 2020

Inhibition of receptor-interacting protein kinase 1 improves experimental non-alcoholic fatty liver disease (Équipe Housset) Amine Majdi, Lynda Aoudjehane, Vlad Ratziu, Tawhidul Islam, Marta B. Afonso, Filomena Conti, Taïeb Mestiri, Marie Lagouge, Fabienne Foufelle, Florine Ballenghien1, Tatiana Ledent, Marthe Moldes, Axelle Cadoret, Laura Fouassier, Jean-Louis Delaunay, Tounsia Aït-Slimane, Gilles Courtois, Bruno Fève, Olivier Scatton, Carina Prip-Buus, Cecília M.P. Rodrigues, Chantal Housset, Jérémie Gautheron

J Hepatol. 2019 [Epub ahead of print] Background & Aims : In non-alcoholic fatty liver disease (NAFLD), hepatocytes can undergo necroptosis: a regulated form of necrotic cell death...

28 - Avril - 2020

Photothermal Depletion of Cancer-Associated Fibroblasts Normalizes Tumor Stiffness in Desmoplastic Cholangiocarcinoma (Équipe Housset) Alba Nicolás-Boluda, Javier Vaquero, Gautier Laurent, Gilles Renault, Rana Bazzi, Emmanuel Donnadieu, Stéphane Roux, Laura Fouassier, Florence Gazeau

ACS Nano. 2020;14(5):5738-53 Physical oncology recognizes tissue stiffness mediated by activation of cancer-associated fibroblasts (CAF) and extracellular matrix remodeling as an active...

CHAPEL Alain

23 - Mai - 2020

Cold-Atmospheric Plasma Induces Tumor Cell Death in Preclinical In Vivo and In Vitro Models of Human Cholangiocarcinoma (Équipe Housset) Javier Vaquero, Florian Judee, Marie Vallette, Henri Decauchy, Ander Arbelaiz, Lynda Aoudjehane, Olivier Scatton, Ester Gonzalez-Sanchez, Fatiha Merabtene, Jérémy Augustin, Chantal Housset, Thierry Dufour, Laura Fouassier

Cancers (Basel). 2020;12(5) Through the last decade, cold atmospheric plasma (CAP) has emerged as an innovative therapeutic option for cancer treatment. Recently, we have set up a...

11 - Décembre - 2020

Introduction to host microbiome symbiosis in health and disease (Équipe Mohty) Florent Malard, Joel Dore, Beatrice Gaugler, Mohamad Mohty

Mucosal Immunol. 2020 Humans share a core intestinal microbiome and yet human microbiome differs by genes, species, enterotypes (ecology), and gene count (microbial diversity). Achievement...

CHAQUIN Michael

CHASTRE Eric

03 - Octobre - 2020

High-dose post-transplant cyclophosphamide impairs gammadelta T-cell reconstitution after haploidentical haematopoietic stem cell transplantation using low-dose antithymocyte globulin and peripheral blood stem cell graft (Équipe Mohty) Nicolas Stocker, Béatrice Gaugler, Myriam Labopin, Agathe Farge, Yishan Ye, Laure Ricard, Eolia Brissot, Remy Dulery, Simona Sestili, Giorgia Battipaglia, Clemence Mediavilla, Annalisa Paviglianiti, Anne Banet, Van De Zoe Wyngaert, Tounes Ledraa, Mohamad Mohty, Florent Malard,

Clin Transl Immunology. 2020;9(9):e1171 OBJECTIVES : Haploidentical haematopoietic cell transplantation (Haplo-HCT) using peripheral blood stem cell (PBSC) grafts and post-transplant...

CHAUFFIER-LOUATI Karine

10 - Juillet - 2020

Arsenic trioxide induces regulatory functions of plasmacytoid dendritic cells through interferon- alpha inhibition (Équipe Mohty ) Yishan Ye, Laure Ricard, Lama Siblany, Nicolas Stocker, Fréderic De Vassoigne, Eolia Brissot, Baptiste Lamarthee, Arsène Mekinian, Mohamad Mohty, Béatrice Gaugler, Florent Malard

Acta Pharm Sin B. 2020;10(6):1061-72 Arsenic trioxide (As2O3) is recently found to have therapeutic potential in systemic sclerosis (SSc), a life-threatening multi-system fibrosing...

CHAZOUILLÈRES Olivier

04 - Juin - 2020

Plasmacytoid dendritic cell biology and its role in immune-mediated diseases (Équipe Mohty) Yishan Ye, Béatrice Gaugler, Mohamad Mohty, Florent Malard

Clin Transl Immunology. 2020;9(5):e1139 Plasmacytoid dendritic cells (pDCs) are a unique subset of dendritic cells specialised in secreting high levels of type I interferons. pDCs play a...

15 - Décembre - 2020

Insights from the genetic characterization of central precocious puberty associated with multiple anomalies (Équipe Netchine) Ana Pinheiro Machado Canton, Ana Cristina Victorino Krepischi, Luciana Ribeiro Montenegro, Silvia Costa, Carla Rosenberg, Virginie Steunou, Marie-Laure Sobrier, Lucas Santana, Rachel Sayuri Honjo, Chong Ae Kim, Francis de Zegher, Jan Idkowiak, Lorna C. Gilligan, Wiebke Arlt, Mariana Ferreira de Assis Funari, Alexander Augusto de Lima Jorge, Berenice Bilharinho Mendonca, Irene Netchine, Vinicius Nahime Brito, Ana Claudia Latronico

Hum Reprod. 2021 Jan 25;36(2):506-518 STUDY QUESTION : Is there an (epi)genetic basis in patients with central precocious puberty (CPP) associated with multiple anomalies that unmasks...

22 - Septembre - 2020

Changes in circulating miRNA19a-3p precede insulin resistance programmed by intra-uterine growth retardation in mice (Équipe Netchine / Fève / Seksik - Sokol) Sarah Saget, Rong Cong, Lyvianne Decourtye, Marie-Laure Endale, Laetitia Martinerie, Clemence Girardet, Claire Perret, Maud Clemessy, Patricia Leneuve, Laetitia Dinard, Mohand Badreddine Oumoussa, Dominique Farabos, Antonin Lamaziere, Marc Lombes, Marthe Moldes, Bruno Feve, David Tregouet, Le Yves Bouc, Laurent Kappeler

Mol Metab. 2020;42:101083 OBJECTIVE : Individuals born with intrauterine growth retardation (IUGR) are more prone to cardio-metabolic diseases as adults, and environmental changes during...

23 - Septembre - 2020

Derivation and Validation of a Predictive Score for Disease Worsening in Patients with COVID-19 (Équipe Larsen-Sabbah) Grigoris T. Gerotziafas, Theodoros N. Sergentanis, Guillaume Voiriot, Ludovic Lassel, Chryssa Papageorgiou, Alexandre Elabbadi, Matthieu Turpin, Patrick Vandreden, Loula Papageorgiou, Theodora Psaltopoulou, Evangelos Terpos, Meletios-Athanasios Dimopoulos, Antoine Parrot, Jacques Cadranel, Gilles Pialoux, Muriel Fartoukh, Ismail Elalamy

Thromb Haemost. 2020 The prospective observational cohort study COMPASS-COVID-19 aimed to develop a risk assessment model for early identification of hospitalized COVID-19 patients at risk...

CHIGNARD Nicolas

14 - Septembre - 2020

Guidance for the Management of Patients with Vascular Disease or Cardiovascular Risk Factors and COVID-19: Position Paper from VAS-European Independent Foundation in Angiology/Vascular Medicine (Équipe Larsen-Sabbah) Grigoris T. Gerotziafas, Mariella Catalano, Mary-Paula Colgan, Zsolt Pecsvarady, Jean Claude Wautrecht, Bahare Fazeli, Dan-Mircea Olinic, Katalin Farkas, Ismail Elalamy, Anna Falanga, Jawed Fareed, Chryssa Papageorgiou, Rosella S. Arellano, Petros Agathagelou, Darco Antic, Luciana Auad, Ljiljana Banfic, John R. Bartolomew, Bela Benczur, Melissa B. Bernardo, Francesco Boccardo, Renate Cifkova, Benilde Cosmi, Sergio De Marchi, Evangelos Dimakakos, Meletios A. Dimopoulos, Gabriel Dimitrov, Isabelle

Thromb Haemost. 2020 COVID-19 is also manifested with hypercoagulability, pulmonary intravascular coagulation, microangiopathy, and venous thromboembolism (VTE) or arterial thrombosis....

CHORFI Louise

01 - Juin - 2020

Broad-spectrum antiviral activity of naproxen: from Influenza A to SARS-CoV-2 Coronavirus (Équipe Sabbah) Olivier Terrier, Sébastien Dilly, Andrés Pizzorno, Julien Henri, Francis Berenbaum, Bruno Lina, Bruno Fève, Frédéric Adnet, Michèle Sabbah, Manuel Rosa-Calatrava, Vincent Maréchal, Anny Slama Schwok

bioRxiv 2020 There is an urgent need for specific antiviral drugs directed against SARS-CoV-2 both to prevent the most severe forms of COVID-19 and to reduce viral excretion and subsequent...

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