Impact of gut fungal and bacterial communities on the outcome of allogeneic hematopoietic cell transplantation (Équipe Mohty)

21 - Juillet - 2021

Florent Malard, Aonghus Lavelle, Giorgia Battipaglia, Béatrice Gaugler, Rémy Dulery, Eolia Brissot, Clémence Mediavilla, Sarah Jegou, Nathalie Rolhion, Tounes Ledraa, Razan Mohty, Harry Sokol, Mohamad Mohty

Mucosal Immunol 14 (2021): 1127-1132

Patients receiving allogeneic hematopoietic cell transplantation (alloHCT) were previously shown to display a bacterial gut dysbiosis; however, limited data are available regarding the role of fungal microbiota in these patients. We evaluated the bacterial and fungal composition of the fecal microbiota at day 0 of alloHCT. Higher bacterial diversity was associated with an improved overall survival (OS) and disease-free survival (DFS). While fungal diversity had no impact on patient outcomes, we observed that high versus low relative abundance of Candida albicans in alloHCT patients at day 0 was associated with a significantly lower OS, DFS and graft-versus-host-free, relapse-free survival (GRFS) (p = 0.0008, p = 0.0064 and p = 0.026, respectively). While these results are limited by low patient numbers and low fungal read counts in some samples, they suggest a potentially important role for C albicans in alloHCT.

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