Résultat de recherche

09 - Juin - 2022

3-oxo-C12:2-HSL, quorum sensing molecule from human intestinal microbiota, inhibits pro-inflammatory pathways in immune cells via bitter taste receptors (Équipe Seksik-Sokol) Garance Coquant, Doriane Aguanno, Loïc Brot, Christine Belloir, Julie Delugeard, Nathalie Roger, Hang-Phuong Pham, Loïc Briand, Marielle Moreau, Luisa de Sordi, Véronique Carriere, Jean-Pierre Grill, Sophie Thenet, Philippe Seksik

Sci Rep 2022; 12: 9440 In the gut ecosystem, microorganisms regulate group behaviour and interplay with the host via a molecular system called quorum sensing (QS). The QS molecule...

BORDE Chloé

06 - Décembre - 2022

Impact of IBD-Associated Dysbiosis on Bacterial Quorum Sensing Mediated by Acyl-Homoserine Lactone in Human Gut Microbiota (Équipe Seksik/Sokol) Nathan Grellier, Marcelino T. Suzuki, Loïc Brot, Alice M.S.Rodrigues, Lydie Humbert, Karine Escoubeyrou, Dominique Rainteau, Jean-Pierre Grill, Raphael Lami, Philippe Seksik

Int J Mol Sci. 2022 Dec 6;23(23):15404 Intestinal dysbiosis is a key feature in the pathogenesis of inflammatory bowel disease (IBD). Acyl-homoserine lactones (AHL) are bacterial...

BORELAND William

26 - Février - 2022

Impact of the Ileal Microbiota on Surgical Site Infections in Crohn's Disease: A Nationwide Prospective Cohort (Équipe Seksik - Sokol) Clément Julien, Emre Anakok, Xavier Treton, Maria Nachury, Stéphane Nancey, Anthony Buisson, Mathurin Fumery, Jérôme Filippi, Léon Maggiori, Yves Panis, Philippe Zerbib, Yves François, Anne Dubois, Charles Sabbagh, Amine Rahili, Philippe Seksik, Matthieu Allez, Jérémie H. Lefèvre, Anna Bonnet, Laura Beyer-Berjot, Harry Sokol

J Crohns Colitis 2022 BACKGROUND : Surgery is performed in 50-70% of Crohn's disease (CD) patients, and its main risk is surgical site infection (SSI). The microbiota has been extensively...

01 - Juin - 2022

Fecal microbiota and bile acids in IBD patients undergoing screening for colorectal cancer (Équipe Seksik/Sokol) Aonghus Lavelle, Stéphane Nancey, Jean-Marie Reimund, David Laharie, Philippe Marteau, Xavier Treton, Matthieu Allez, Xavier Roblin, Georgia Malamut, Cyriane Oeuvray, Nathalie Rolhion, Xavier Dray, Dominique Rainteau, Antonin Lamazière, Émilie Gauliard, Julien Kirchgesner, Laurent Beaugerie, Philippe Seksik, Laurent Peyrin-Biroulet, Harry Sokol

Gut Microbes 2022; 14: 2078620 Due to the potential role of the gut microbiota and bile acids in the pathogenesis of both inflammatory bowel disease (IBD) and sporadic colorectal cancer, we...

11 - Mai - 2022

Human CD4+/CD8alpha+ regulatory T cells induced by Faecalibacterium prausnitzii protect against intestinal inflammation (Équipe Seksik-Sokol) Sothea Touch, Emmanuelle Godefroy, Nathalie Rolhion, Camille Danne, Cyriane Oeuvray, Marjolène Straube, Chloé Galbert, Loïc Brot, Iria Alonso Salgueiro, Sead Chadi, Tatiana Ledent, Jean-Marc Chatel, Philippe Langella, Francine Jotereau, Frédéric Altare, Harry Sokol

JCI Insight 2022 Faecalibacterium prausnitzii (F. prausnitzii), a dominant bacterium of the human microbiota, is decreased in patients with inflammatory bowel diseases (IBD) and exhibits...

BOUCHAMA Lyes

BOULOUSSA Hedi

08 - Mai - 2021

Osteoarthritis and gut microbiome (Équipe Berenbaum) Marie Binvignat, Harry Sokol, Encarnita Mariotti-Ferrandiz, Francis Berenbaum, Jérémie Sellam

Joint Bone Spine 88 (2021): 105203

BOUMENDIL Ariane

Hypertension meets osteoarthritis - revisiting the vascular aetiology hypothesis (Équipe Berenbaum) Karen Ching, Xavier Houard, Francis Berenbaum, Chunyi Wen

Nat Rev Rheumatol 17 (2021): 533-549 Osteoarthritis (OA) is a whole-joint disease characterized by subchondral bone perfusion abnormalities and neovascular invasion into the synovium and...

04 - Juin - 2021

Regulation of the acetylcholine/alpha7nAChR anti-inflammatory pathway in COVID-19 patients (Équipe Berenbaum) Alice Courties, Jérémy Boussier, Jérôme Hadjadj, Nader Yatim, Laura Barnabei, Hélène Père, David Veyer, Solen Kerneis, Nicolas Carlier, Frédéric Pene, Frédéric Rieux-Laucat, Bruno Charbit, Vincent Bondet, Darragh Duffy, Francis Berenbaum, Benjamin Terrier, Jérémie Sellam

Sci Rep 2021 Vol. 11 Issue 1 Pages 11886 The cholinergic system has been proposed as a potential regulator of COVID-19-induced hypercytokinemia. We investigated whole-blood expression of...

07 - Février - 2021

Vagus nerve stimulation in musculoskeletal diseases (Équipe Berenbaum) Alice Courties, Francis Berenbaum, Jérémie Sellam

Joint Bone Spine 88 (2021): 105149 The vagus nerve is the main nerve of the parasympathetic autonomic nervous system. Beyond its vegetative functions, the vagus nerve possesses...

11 - Décembre - 2020

The differentiation of prehypertrophic into hypertrophic chondrocytes drives an OA-remodeling program and IL-34 expression (Équipe Berenbaum) S. van Eegher, M. L. Perez-Lozano, I. Toillon, D. Valour, A. Pigenet, D. Citadelle, C. Bourrier, S. Courtade-Gaiani, L. Grégoire, D. Cleret, S. Malbos, G. Nourissat, A. Sautet, M. H.Lafage-Proust, P. Pastoureau, G. Rolland-Valognes, F. De Ceuninck, F. Berenbaum, X. Houard

Osteoarthritis Cartilage 29 (2021): 257-268 OBJECTIVES : We hypothesize that chondrocytes from the deepest articular cartilage layer are pivotal in maintaining cartilage integrity and that...

12 - Octobre - 2021

Risk factors for Pseudomonas aeruginosa airway infection and lung function decline in children with cystic fibrosis (Équipe Corvol) Julie Mésinèle, Manon Ruffin, Astrid Kemgang, Loïc Guillot, Pierre-Yves Boelle, Harriet Corvol

J Cyst Fibros. 2021 Background Cystic fibrosis (CF) lung disease is characterised by recurrent Pseudomonas aeruginosa (Pa) infections, leading to structural lung damage and decreased...

BOUTROS Rita Maria

07 - Décembre - 2021

Flagellin From Pseudomonas aeruginosa Modulates SARS-CoV-2 Infectivity in Cystic Fibrosis Airway Epithelial Cells by Increasing TMPRSS2 Expression (Équipe Corvol) Manon Ruffin, Jeanne Bigot, Claire Calmel, Julia Mercier, Maelle Givelet, Justine Oliva, Andres Pizzorno, Manuel Rosa-Calatrava, Harriet Corvol, Viviane Balloy, Olivier Terrier, Loic Guillot

Front Immunol 2021 Vol. 12 Pages 714027 In the coronavirus disease 2019 (COVID-19) health crisis, one major challenge is to identify the susceptibility factors of severe acute respiratory...

BOUZIDI Houda Ghozlane

14 - Novembre - 2020

Role of adipose tissues in osteoarthritis (Équipe Berenbaum) Natalia Zapata-Linares, Florent Eymard, Francis Berenbaum, Xavier Houard

Curr Opin Rheumatol 33 (2021): 84-93 PURPOSE OF REVIEW : Epidemiologic studies reveal that the link between obesity and osteoarthritis cannot be uniquely explained by overweight-associated...

BRAX Sylvain

16 - Septembre - 2021

Peripheral and central immune system crosstalk in Alzheimer disease - a research prospectus (Équipe Dorothée) Brianne M. Bettcher, Malu G. Tansey, Guillaume Dorothée, Michael T. Heneka

Nat Rev Neurol. 2021 Dysregulation of the immune system is a cardinal feature of Alzheimer disease (AD), and a considerable body of evidence indicates that pathological alterations in...

13 - Juin - 2021

Letter to the editor: Serum anti-Abeta antibodies in cerebral amyloid angiopathy (Équipe Dorothée) Yannick Chantran, Jean Capron, Diana Doukhi, Johanna Felix, Mélanie Feroul, Florian Kruse, Thomas Chaigneau, Guillaume Dorothée, Thibault Allou, Xavier Ayrignac, Zina Barrou, Thomas de Broucker, Corina Cret, Guillaume Turc, Roxane Peres, Anne Wacongne, Marie Sarazin, Dimitri Renard, Charlotte Cordonnier, Sonia Alamowitch, Pierre Aucouturier

Autoimmun Rev. 2021;20(8):102870

BRIOUDE Frédéric

03 - Février - 2021

Glial cells and adaptive immunity in frontotemporal dementia with tau pathology (Équipe Dorothée) Iain J. Hartnell, David Blum, James A.R. Nicoll, Guillaume Dorothée, Delphine Boche

Brain. 2021 Neuroinflammation is involved in the aetiology of many neurodegenerative disorders including Alzheimer's disease, Parkinson's disease and motor neuron disease. Whether...

BRISSOT DAVAINE Eolia

17 - Mai - 2021

Performance of Next-Generation Sequencing for the Detection of Microsatellite Instability in Colorectal Cancer With Deficient DNA Mismatch Repair (Équipe Duval) Toky Ratovomanana, Romain Cohen, Magali Svrcek, Florence Renaud, Pascale Cervera, Aurélie Siret, Quentin Letourneur, Olivier Buhard, Pierre Bourgoin, Erell Guillerm, Coralie Dorard, Rémy Nicolle, Mira Ayadi, Mehdi Touat, Franck Bielle, Marc Sanson, Philippe Le Rouzic, Marie-Pierre Buisine, Guillaume Piessen, Ada Collura, Jean-Francois Fléjou, Aurélien de Reynies, Florence Coulet, François Ghiringhelli, Thierry André, Vincent Jonchère, Alex Duval

Gastroenterology 161 (2021): 814-826 e7 BACKGROUND & AIMS : Next-generation sequencing (NGS) was recently approved by the United States Food and Drug Administration to detect...

BRONES Clara

09 - Janvier - 2021

Cholangiopathy aggravation is caused by VDR ablation and alleviated by VDR-independent vitamin D signaling in ABCB4 knockout mice (Équipe Housset) Ester Gonzalez-Sanchez, Haquima El Mourabit, Marion Jager, Marie Clavel, Sophie Moog, Javier Vaquero, Tatiana Ledent, Axelle Cadoret, Jérémie Gautheron, Laura Fouassier, Dominique Wendum, Nicolas Chignard, Chantal Housset

Biochim Biophys Acta Mol Basis Dis. 2021;1867(4):166067 BACKGROUND & AIMS : Cholangiopathies are chronic liver diseases in which damaged cholangiocytes trigger a proinflammatory and...

BROT Loïc

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