Dernières publications

Publication de diverses études scientifiques

01 - Septembre - 2022

Genetic alterations shaping tumor response to anti-EGFR therapies (Équipe Gautheron/Housset)

Drug Resist Updat 2022 Vol. 64 Pages 100863 The Epidermal Growth Factor Receptor (EGFR) has been targeted through the development of selective tyrosine kinase inhibitors (TKIs) and...

01 - Septembre - 2022

EASL Clinical Practice Guidelines on sclerosing cholangitis (Équipe Gautheron/Housset)

J Hepatol 2022 Vol. 77 Issue 3 Pages 761-806 Management of primary or secondary sclerosing cholangitis is challenging. These Clinical Practice Guidelines have been developed to provide...

27 - Août - 2022

RIPK3 dampens mitochondrial bioenergetics and lipid droplet dynamics in metabolic liver disease (Équipe Gautheron/Housset / Fève)

Hepatology 2022 BACKGROUND AND AIMS : Receptor-interacting protein kinase 3 (RIPK3) mediates NAFLD progression, but its metabolic function is unclear. Here, we aimed to investigate the...

15 - Juin - 2022

Pollutants: a candidate as a new risk factor for osteoarthritis-results from a systematic literature review (Équipe Berenbaum)

RMD Open 2022; 8 BACKGROUND : Considering non-classical environmental risk factors for osteoarthritis (OA), a systematic literature review (SLR) was performed to summarise existing...

10 - Juin - 2022

IGF2: Development, Genetic and Epigenetic Abnormalities (Équipe Netchine)

Cells 2022 Vol. 11 Issue 12 Pages 1886 In the 30 years since the first report of parental imprinting in insulin-like growth factor 2 (Igf2) knockout mouse models, we have learnt much about...

09 - Juin - 2022

3-oxo-C12:2-HSL, quorum sensing molecule from human intestinal microbiota, inhibits pro-inflammatory pathways in immune cells via bitter taste receptors (Équipe Seksik-Sokol)

Sci Rep 2022; 12: 9440 In the gut ecosystem, microorganisms regulate group behaviour and interplay with the host via a molecular system called quorum sensing (QS). The QS molecule...

09 - Juin - 2022

Deciphering pathological remodelling of the human cartilage extracellular matrix in osteoarthritis at the supramolecular level (Équipe Berenbaum)

Nanoscale 2022; 14: 8691-8708 The extracellular matrix (ECM) of articular cartilage is a three-dimensional network mainly constituted of entangled collagen fibrils and interfibrillar...

02 - Juin - 2022

Consequences of the Hsp110DE9 mutation in tumorigenesis and the 5-fluorouracil-based chemotherapy response in Msh2-deficient mice (Équipe Duval)

Cell Mol Life Sci 2022; 79: 332 Heat shock proteins (HSPs) play oncogenic roles in human tumours. We reported a somatic inactivating mutation of HSP110 (HSP110DE9) in mismatch...

01 - Juin - 2022

Fecal microbiota and bile acids in IBD patients undergoing screening for colorectal cancer (Équipe Seksik/Sokol)

Gut Microbes 2022; 14: 2078620 Due to the potential role of the gut microbiota and bile acids in the pathogenesis of both inflammatory bowel disease (IBD) and sporadic colorectal cancer, we...

28 - Mai - 2022

Loss of thymidine phosphorylase activity disrupts adipocyte differentiation and induces insulin-resistant lipoatrophic diabetes (Équipe Gautheron/Housset / Fève)

BMC Med. 2022 Mar 28;20(1):95 BACKGROUND : Thymidine phosphorylase (TP), encoded by the TYMP gene, is a cytosolic enzyme essential for the nucleotide salvage pathway. TP catalyzes the...
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