Dernières publications CRSA, Centre de Recherche de l’hôpital Saint-Antoine

18 - Décembre - 2025

RIPK1 inhibition reduces biliary injury and fibrosis in primary sclerosing cholangitis

Sci Adv. 2025 Dec 19;11(51):eadz7907 Primary sclerosing cholangitis (PSC) is a chronic cholestatic liver disease with no effective curative therapies. Necroptosis, a regulated...

22 - Novembre - 2025

ABCB4 disease-causing variants S242R, S346I, T437I and T1077M significantly impair its function and display differential sensitivity to potentiators

Sci Rep. 2025 Nov 22. The hepato-canalicular adenosine triphosphate (ATP)-binding cassette transporter ABCB4/MDR3 is responsible of the secretion of phosphatidylcholine (PC) into...

07 - Novembre - 2025

Saccharomyces boulardii CNCM I-745 mitigates antibiotic-induced gut microbiome functional alterations independently of the host

Gut Microbes. 2025 Dec 31;17(1):2575924 ABSTRACT: The probiotic Saccharomyces boulardii CNCM I-745 (Sb) is widely prescribed to alleviate antibiotic-induced diarrhea, yet its mode of...

06 - Novembre - 2025

MALADIES FIBRO-INFLAMMATOIRES D'ORIGINE METABOLIQUES ET BILIAIRES DU FOIE

https://www.crsa.fr/equipe-jeremie-gautheron.html

28 - Octobre - 2025

Targeting the gut microbiome in inflammatory bowel disease: from concept to clinical reality

Intest Res. 2025 Oct;23(4):396-404 ABSTRACT: The gut microbiota, a complex community of trillions of microorganisms inhabiting the human gastrointestinal tract, has emerged as a...

21 - Octobre - 2025

Microbial metabolite indole-3-propionic acid drives mitochondrial respiration in CD4+ T cells to confer protection against intestinal inflammations

Nat Metab. 2025 Oct 21 ABSTRACT: The gut microbiota and its metabolites critically regulate immune cell phenotype, function and energy metabolism. We screened a collection of gut...

10 - Octobre - 2025

Antifungal activity of ETD151 against azole-susceptible and -resistant Aspergillus fumigatus clinical isolates (Équipe Corvol & Guillot)

Aspergillus fumigatus is an opportunistic pathogen responsible for a wide spectrum of severe diseases, depending on the host's immune status. Current therapeutic options against this...

09 - Octobre - 2025

Immunometabolic reprogramming of macrophages by gut microbiota-derived cadaverine controls colon inflammation

Cell Host Microbe. 2025 Sep 30:S1931-3128(25)00375-0. ABSTRACT: Cadaverine is a polyamine produced by the gut microbiota with links to health and disease, notably inflammatory bowel...

08 - Octobre - 2025

Gut microbiota alterations are linked to COVID-19 severity in North African and European populations

NPJ Biofilms Microbiomes. 2025 juin 13;11(1):106 ABSTRACT: Although COVID-19 primarily affects the respiratory system, many patients experience gastrointestinal symptoms, suggesting a...

06 - Octobre - 2025

Adipocyte-specific Mlkl knockout mitigates obesity-induced metabolic dysfunction by enhancing mitochondrial functions

Cell Death Dis. 2025 Oct 6;16(1):683 Obesity is a global epidemic characterized by chronic low-grade inflammation and metabolic dysfunction, with adipose tissue playing a pivotal...

Dernières publications

Publication de diverses études scientifiques