Nat Commun. 2018;9(1):1216
Transforming growth factor-beta (TGFbeta) signaling is initiated by the type I, II TGFbeta receptor (TbetaRI/TbetaRII) complex. Here we report the formation of an...
Gut Microbes. 2018;9(2):131-42
Gut microbiota dysbiosis has been associated with inflammatory bowel diseases (IBD). In colorectal cancer, the gut microbiota has also been recognized as...
J Cyst Fibros. 2018;17(2):190-203
Background : Cystic fibrosis (CF) lung disease severity is highly variable and dependent on several factors including genetic modifiers. Family with...
Lab Invest. 2018;98(6):696-707
Breast cancer is a major health problem worldwide. In ~15% of breast cancers, the epidermal growth factor receptor HER2, a transmembrane protein, is...
Plant Cell Environ. 2018;41(3):533-47
Xerophyta humilis is a poikilochlorophyllous monocot resurrection plant used as a model to study vegetative desiccation tolerance. Dehydration imposes...
Lab Invest. 2018;98(2):164-74
Nucleoside diphosphate kinases (NDPK) are nucleotide metabolism enzymes encoded by NME genes (also called NM23). Given the fact that not all NME-encoded...
Cancer Res. 2018;78(3):659-70
Preoperative radiotherapy (RT) is a mainstay in the management of rectal cancer, a tumor characterized by desmoplastic stroma containing cancer-associated...
Biochim Biophys Acta Mol Cell Biol Lipids. 2018;1863(2):199-211
Scavenger receptor Class B type 1 (SR-B1) is a lipid transporter and sensor. In intestinal epithelial cells, SR-B1-dependent...
Nat Rev Endocrinol. 2018;14(4):229-49
Beckwith–Wiedemann syndrome (BWS), a human genomic imprinting disorder, is characterized by phenotypic variability that might include overgrowth,...
Med Genet. 2018;55(3):205-13
Background : The 11p15 region contains two clusters of imprinted genes. Opposite genetic and epigenetic anomalies of this region result in two distinct growth...
Gut. 2017;66(12):2160-9
Objective : HCV is intimately linked with the liver lipid metabolism, devoted to the efflux of triacylglycerols stored in lipid droplets (LDs) in the form of...
Science. 2017;358(6364):803-6
Cell division and differentiation depend on massive and rapid organelle remodeling. The mitotic oscillator, centered on the cyclin-dependent kinase...
J Clin Endocrinol Metab. 2017;102(11):3970-8
Context : Anti-Mullerian hormone (AMH) and AMH type II receptor (AMHR2) are overexpressed in granulosa cells (GCs) from women with polycystic...
Best Pract Res Clin Rheumatol. 2017;31(5):661-75
Joint homeostasis is affected by local and systemic processes. Catecholaminergic and cholinergic fibers innervate the synovium, trabecular...
Proc Natl Acad Sci U S A. 2017;114(36):9731-6
When food resources are scarce, endothermic animals can lower core body temperature (Tb). This phenomenon is believed to be part of an adaptive...
Cancer Genomics Proteomics. 2017;14(5):329-39
Background/Aim : The aim of this study was to assess the incidence of MSI in a large series of human hepatocellular carcinomas (HCC) with...
Genet Med. 2018;20(2):250-8
Purpose : Fetal growth is a complex process involving maternal, placental and fetal factors. The etiology of fetal growth retardation remains unknown in many...
F1000Res. 2017;6:724
Nucleoside triphosphate (NTP)s, like ATP (adenosine 5'-triphosphate) and GTP (guanosine 5'-triphosphate), have long been considered sufficiently concentrated and...
Ann Endocrinol (Paris). 2017;78(2):92-5
Abstract
Organism development is controlled by both genetic programs and the environment to insure a reproductive success as adults. Linear...
Biochim Biophys Acta Mol Basis Dis. 2017;1863(7):1699-708
Nuclear receptors (NR), the largest family of transcription factors, control many physiological and pathological processes. To gain...
PLoS One. 2017;12(6):e0179913
Induced pluripotent stem cells hold great potential to produce unlimited amount of differentiated cells as cellular source for regenerative medicine but also...
Diabetes. 2017;66(6):1470-8
Activation of thermogenic beige adipocytes has recently emerged as a promising therapeutic target in obesity and diabetes. Relevant human models for beige...
Gut. 2017;66(6):1039-48
Objective : The bacterial intestinal microbiota plays major roles in human physiology and IBDs. Although some data suggest a role of the fungal microbiota in IBD...
Sci Rep. 2017;7(1):1749
WISP1 (Wnt1-inducible signaling pathway protein-1, also known as CCN4) is a member of the CCN family able to mediate cell growth, transformation and survival in a...
J Med Genet. 2017;54(6):413-6
Background : Type-2 familial partial lipodystrophy (FPLD2) is a rare autosomal dominant lipodystrophic disorder due to mutations in LMNA encoding lamin A/C, a...
Ann Rheum Dis. 2017;76(6):1142-8
Objectives : Compared with subcutaneous adipose tissue (SCAT), infrapatellar fat pad (IFP), the main knee intra-articular adipose tissue (IAAT), has an...
Curr Opin Rheumatol. 2017;29(2):214-22
Purpose of review : Interest in the metabolic syndrome-associated osteoarthritis phenotype is increasing. Here, we summarize recently published...
Hepatology. 2017;65(2):560-70
ABCB4 (MDR3) is an adenosine triphosphate (ATP)-binding cassette (ABC) transporter expressed at the canalicular membrane of hepatocytes, where it mediates...
