bioRxiv 2020
There is an urgent need for specific antiviral drugs directed against SARS-CoV-2 both to prevent the most severe forms of COVID-19 and to reduce viral excretion and subsequent...
Sci Rep. 2020;10(1):8852
The cholinergic system plays a major anti-inflammatory role in many diseases through acetylcholine (Ach) release after vagus nerve stimulation. Osteoarthritis (OA) is...
J Hepatol. 2019 [Epub ahead of print]
Background & Aims : In non-alcoholic fatty liver disease (NAFLD), hepatocytes can undergo necroptosis: a regulated form of necrotic cell death...
Cancers (Basel). 2019;11(12)
Breast adiposity is correlated with body mass index, menopausal status and mammary density. We here wish to establish how these factors influence the cross-talk...
Arthritis Res Ther. 2019;21(1):252
Background : Intra-articular adipose tissues (IAATs) are involved in osteoarthritis (OA) pathophysiology. We hypothesize that mesenchymal cells residing...
J Infect Dis. 2019
Human bronchial epithelial cells play a key role in airway immune homeostasis. We hypothesized that these sentinel cells can remember a previous contact with pathogen...
Biochim Biophys Acta Mol Cell Biol Lipids. 2020;1865(2):158530
The mechanisms leading to the low-grade inflammation observed during obesity are not fully understood. Seeking the initiating...
Clin Exp Rheumatol. 2019;37 Suppl 120(5):48-56
Osteoarthritis (OA) is the most com- mon age-related chronic and disabling joint disease. Long considered to be a “wear and tear”...
J Med Genet. 2019
Background : The type 1 insulin-like growth factor receptor (IGF1R) is a keystone of fetal growth regulation by mediating the effects of IGF-I and IGF-II. Recently, a...
Liver Int. 2019
Background and aims : The ABCC2 gene is implicated in Dubin-Johnson syndrome (DJS), a rare autosomal recessive liver disorder. The primary aim of this study was to determine...
Microbiome. 2019;7(1):111
Background : Normal mammalian development and homeostasis are dependent upon the gut microbiota. Antibiotics, essential for the treatment and prophylaxis of...
Hum Mol Genet. 2019;28(19):3211-8
The persistent Mullerian duct syndrome (PMDS) is a 46,XY disorder of sexual development characterized by the persistence of Mullerian duct derivatives,...
Sleep Med. 2019;on line
Objective ; Imprinting disorders (ID), such as Prader−Willi syndrome (PWS), are associated with sleep-disordered breathing (SDB). No data are available for...
Front Endocrinol (Lausanne). 2019;10:263
We report an original association of complex genetic defects in a patient carrying both an 11p paternal duplication, resulting in the double...
Sci Rep. 2019;9(1):6653
Adenosine triphosphate binding cassette transporter, subfamily B member 4 (ABCB4) is the transporter of phosphatidylcholine at the canalicular membrane of...
Gut. 2019
Objective : Patients with primary sclerosing cholangitis (PSC) were previously shown to display a bacterial gut dysbiosis but fungal microbiota has never been examined in these...
Dev Biol. 2019;448(2):237-46
At the onset of the Ciona intestinalis metamorphosis, the first event is tail regression characterized, by a contraction, an apoptotic wave and Primordial Germ...
Journal of Physics D: Applied Physics. 2019;52(24)
Two atmospheric pressure plasma jet (APPJ) devices—a plasma gun and a plasma Tesla jet—are compared in terms of safety and...
Clin Gastroenterol Hepatol. 2019
Background & Aims : Primary sclerosing cholangitis (PSC) has a variable, often progressive course. Magnetic resonance cholangiography (MRC) is used in...
PLoS Genet. 2019;15(3):e1008018
Several bacteria in the gut microbiota have been shown to be associated with inflammatory bowel disease (IBD), and dozens of IBD genetic variants have been...
Nat Rev Endocrinol. 2019;15(5):299-311
Overgrowth syndromes are a heterogeneous group of rare disorders characterized by generalized or segmental excessive growth commonly associated with...
Nat Rev Gastroenterol Hepatol. 2019;16(6):331-45
The gut microbiota is a dense and diverse ecosystem that is involved in many physiological functions as well as in disease pathogenesis. It...
Nutr Rev. 2019;77(3):129-43
The plasticity of a material corresponds to its capacity to change its feature under the effect of an external action. Intestinal plasticity could be defined as...
Sci. Adv. 2019; 5 : eaau9425
Clinical and molecular overlap in imprinting disorders
Imprinting disorders (ID) often affect growth in humans, leading to diseases with overlapping...
Genetics in Medicine 2019
Purpose : The SERPINA1 Z allele is associated with cystic fibrosis (CF)-related liver disease (CFLD), a common manifestation in patients with CF. We estimated...
Gut. 2019
Objective : We explored the hypothesis that TGR5, the bile acid (BA) G-protein-coupled receptor highly expressed in biliary epithelial cells, protects the liver against BA...
Diabetes. 2019;68(2):305-17
Widely used for their anti-inflammatory and immunosuppressive properties, glucocorticoids are nonetheless responsible for the development of diabetes and...
Arthritis Res Ther. 2019;21(1):18
Background : Accumulation of advanced glycation end-products (AGEs) is involved in age-related osteoarthritis (OA). Glyoxalase (Glo)-1 is the main enzyme...
Toxicol Sci. 2019;168(2):474-85
Drug-induced cholestasis is mostly intrahepatic and characterized by alterations of bile canaliculi dynamics and morphology as well as accumulation of bile...
