Dernières publications

Publication de diverses études scientifiques

20 - Février - 2019

Transcriptional profiling at DLK1/MEG3 domain explains clinical overlap between imprinting disorders (Équipe Netchine)

Sci. Adv. 2019; 5 : eaau9425 Clinical and molecular overlap in imprinting disorders Imprinting disorders (ID) often affect growth in humans, leading to diseases with overlapping...

11 - Février - 2019

SERPINA1 Z allele is associated with cystic fibrosis liver disease (Équipe Corvol)

Genetics in Medicine 2019 Purpose : The SERPINA1 Z allele is associated with cystic fibrosis (CF)-related liver disease (CFLD), a common manifestation in patients with CF. We estimated...

07 - Février - 2019

TGR5-dependent hepatoprotection through the regulation of biliary epithelium barrier function (Équipe Seksik/Sokol)

Gut. 2019 Objective : We explored the hypothesis that TGR5, the bile acid (BA) G-protein-coupled receptor highly expressed in biliary epithelial cells, protects the liver against BA...

01 - Février - 2019

Adipocyte Glucocorticoid Receptor Deficiency Promotes Adipose Tissue Expandability and Improves the Metabolic Profile Under Corticosterone Exposure (Équipe Fève)

Diabetes. 2019;68(2):305-17 Widely used for their anti-inflammatory and immunosuppressive properties, glucocorticoids are nonetheless responsible for the development of diabetes and...

11 - Janvier - 2019

Impairment of glyoxalase-1, an advanced glycation end-product detoxifying enzyme, induced by inflammation in age-related osteoarthritis (Équipe Berenbaum)

Arthritis Res Ther. 2019;21(1):18 Background : Accumulation of advanced glycation end-products (AGEs) is involved in age-related osteoarthritis (OA). Glyoxalase (Glo)-1 is the main enzyme...

10 - Janvier - 2019

Predictive Value of Cellular Accumulation of Hydrophobic Bile Acids As a Marker of Cholestatic Drug Potential (Équipe Seksik/Sokol)

Toxicol Sci. 2019;168(2):474-85 Drug-induced cholestasis is mostly intrahepatic and characterized by alterations of bile canaliculi dynamics and morphology as well as accumulation of bile...

01 - Janvier - 2019

Adaptive beta-Cell Neogenesis in the Adult Mouse in Response to Glucocorticoid-Induced Insulin Resistance (Équipe Fève)

Diabetes. 2019;68(1):95-108 Both type 1 and type 2 diabetes are characterized by deficient insulin secretion and decreased beta-cell mass. Thus, regenerative strategies to increase...

01 - Janvier - 2019

Glucocorticoid-induced insulin resistance is related to macrophage visceral adipose tissue infiltration (Équipe Fève)

J Steroid Biochem Mol Biol. 2019;185:150-62 Insulin resistance is frequently present in patients with glucocorticoid (GC) excess (Cushing's syndrome) or treated with high doses of GCs....

Hypertension meets osteoarthritis - revisiting the vascular aetiology hypothesis (Équipe Berenbaum)

Nat Rev Rheumatol 17 (2021): 533-549 Osteoarthritis (OA) is a whole-joint disease characterized by subchondral bone perfusion abnormalities and neovascular invasion into the synovium and...

Gut microbiota diversity after autologous fecal microbiota transfer in acute myeloid leukemia patients (Équipe Mohty)

Nat Commun 12 (2021): 3084 Acute myeloid leukemia (AML) intensive chemotherapy combined with broad-spectrum antibiotics, leads to gut microbiota dysbiosis promoting pathological conditions...
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