12/05-2023 -Chunyi WEN : Endothelin signalling in health and disease in post-COVID era
04 - Mai - 2023
LES LUNDIS DE SAINT-ANTOINE
Bâtiment Kourilsky - 14h–15h
salle de cours du service de rhumatologie située au 1er étage du Bât de l'Horloge,
184 rue du Faubourg Saint-Antoine, Paris
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VENDREDI 12 MAI 2023
Endothelin signalling in health and disease in post-COVID era
Chunyi WEN
Associate Professor in the Department of Biomedical engineering of Hong Kong Polytechnic University
invité par Equipe de Francis BERENBAUM
(Equipe Francis BERENBAUM (xavier.houard@sorbonne-universite.fr))
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Dr. Chunyi WEN, Associate Professor in Department of Biomedical Engineering, leads a research group in Hong Kong to combat osteoarthritis.
In his early academic career, Dr. Wen’s work on bone and joint injury and degeneration from mechanism towards therapeutics. He contributed to discovery of TGF-beta1 as a key regulator in subchondral bone disturbance and osteoarthritis pathogenesis (Nature Medicine 2013). His work has been recognized by Young Investigator Award, Mr. Savio Woo and Mrs. Pattie Woo Travel Fellowship, AOSpine East Asia (AOSEA) Research Grant award and AOSEA Travel Grant, and Oldendorf Award. Since joining PolyU BME, Dr. Wen’s research centers on vascular etiology of osteoarthritis. Dr. Wen and his team finally identified endothelin-1 (ET-1), the most potent vasoconstrictor in hypertension, contributing to articular chondrocyte senescence and osteoarthritis pathology (Osteoarthritis and Cartilage 2015 and 2020). It substantiates the vascular etiology hypothesis of osteoarthritis and opens a new avenue for discovery of novel mechanism-based disease-modifying therapies against osteoarthritis (Nature Review Rheumatology 2021). Meanwhile, we kicked off formal research collaboration with world-leading research institutes such as Sorbonne University in Paris (Prof. Francis Berenbaum, PROCORE-France/Hong Kong Joint Research Scheme and INSERM International Research Program).
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