05/10/2026 - Djamel DRIDER :Study of the Regulation and Transport Mechanisms of Enterocin DD14 and Exploration of Its Potential Applications

LES LUNDIS DE SAINT-ANTOINE

Bâtiment Kourilsky - 11h–12h

Salle des Conférences (Rez de Chaussée),

184 rue du Faubourg Saint-Antoine, Paris

***

5 OCTOBRE 2026

Study of the Regulation and Transport Mechanisms of Enterocin DD14 and Exploration of Its Potential Applications

Djamel DRIDER

Full Professor Lille university, UMR-T BioEcoAgro INRAE 1158 Cité scientifique, Polytech-Lille 59655 Vileneuve d’Ascq

invitée par Joëlle SOBCZAK équipe de Joëlle SOBCZAK & Mathieu BOISSAN

(joelle.sobczak@inserm.fr)

Enterocin DD14 (EntDD14) is a leaderless two-peptide bacteriocin, which is produced by Enterococcus faecalis 14, a strain originally isolated from meconium [1,2]. The synthesis of EntDD14 is encoded by the ddA and ddB genes, which are under the control of the P1 promoter. The other genes within the genetic cluster (ddC, ddD, ddE, ddF, ddG, ddH, ddI, and ddJ), involved in bacteriocin transport, immunity, and secretion, are regulated by the P2 promoter.
In this presentation, we will discuss the regulation [3, 4, 5] and transport [6] mechanisms of EntDD14. Beyond these fundamental aspects, we will also highlight its application potential through the elucidation of its mode of action [7] and the evaluation of its anti-Staphylococcus aureus activity both in vitro and in vivo [8,9]. Taken together, these studies establish EntDD14 as a model among leaderless bacteriocins. The knowledge gained contributes to a better understanding of the biology of these antimicrobial peptides and opens promising perspectives for their exploitation in the fight against bacterial infections in the era of antibiotic resistance.

References

1. Al Atya AK and others (2015). Frontiers in Microbiology. doi: 10.3389/fmicb.2015.00227.
2. Caly DL and others (2017). International Journal of Antimicrobial Agents. doi: 10.1016/j.ijantimicag.2016.11.01
3. Ladjouzi R and others (2022). Gene. 30;833:146610. doi: 10.1016/j.gene.2022.146610.
4. Ladjouzi R and others (2023). Scientific Reports. doi: 10.1038/s41598-023-48619-y.
5. Cochard C and others (2026), PNAS Nexus. https://doi.org/10.1093/pnasnexus/pgag192
6. Pérez-Ramos A and others (2021). International Journal of Molecular Sciences. doi: 10.3390/ijms222312877.
7. Belguesmia Y and others (2024). International Journal of Biological Macromolecules. doi: 10.1016/j.ijbiomac.2024.135716.
8. Bendjeddou K and others D (2021). Beneficial Microbes. doi: 10.3920/BM2020.0155.
9. Belguesmia Y and others (2021). Microbiological Research. doi: 10.1016/j.micres.2021.126864.