Faculté de médecine Pierre et Marie Curie – Site Saint-Antoine – 10ème étage
27, rue Chaligny – 75571 PARIS cedex 12
Our team is focused on graft-versus host reactions after allogeneic stem cell transplantation. Allogeneic hematopoietic stem cell transplantation (allo-SCT) has proven to be an effective therapy for a variety of life-threatening malignancies. However, allo-SCT is limited by the immunologic recognition and destruction of host tissues, termed graft-versus-host disease (GVHD). We develop translational studies aiming to decipher the different steps of the regulatory loops linking innate and adaptive immunity in GVHD target tissues. For this purpose, we characterize the status and function of dendritic cell subsets in GVHD as well as the different T helper subsets (Th1, Th17, Th22, Tfh and Treg) infiltrating the target tissues of GVHD (mainly skin and gut) or in the periphery before and after GVHD onset, and the nature and contribution of rare immune cells such as iNKT cells contained within the allogeneic graft to GVHD initiation or regulation. These approaches are dedicated towards identification of GVHD biomarkers for predicting GVHD response to therapy, measurement of GVHD activity and distinguishing irreversible damage from continued GVHD activity, predicting the risk of developing long term deleterious GVHD, providing positive diagnosis of GVHD in clinically conflicting situations, and assessing prognosis of GVHD to guide therapeutic decisions.
Selected Publications :
