23/03-2020 - Luisa de Sordi : Des tueurs en série comme alliés : les bactériophages patrouillent le microbiote intestinal

18 - Mars - 2020

LES LUNDIS DE SAINT-ANTOINE

Bâtiment Kourilsky - 13h–14h

Salle des Conférences (Rez de Chaussée),

184 rue du Faubourg Saint-Antoine, Paris

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LUNDI 23 MARS 2020

 Des tueurs en série comme alliés : les bactériophages patrouillent le microbiote intestinal

Luisa de Sordi

Centre de Recherche Saint-Antoine

Equipe P. Seksik/H. Sokol (luisa.de_sordi@sorbonne-universite.fr)

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Viruses that infect bacteria, or bacteriophages (phages), are among the most abundant entities in the gut microbiome. However, the mechanisms by which they infect and persist as unique viral pools in the intestinal tract remain poorly understood. We use animal models to study the mechanisms of phage – bacteria interactions. I will present our results on how phages can be used to modulate the composition of the intestinal microbiota and how the coevolution with their hosts drives the expansion of viral and bacterial diversity. Our data suggest that the modulation of phage-bacteria infection networks is relative to the opportunities for coevolution encountered in the intestinal tract, and that multiple predator-prey dynamics are perpetuated in parallel, generating and maintaining the intestinal microbial equilibrium.

Centre de Recherche
Saint-Antoine
UMR_S 938

Hôpital St-Antoine

Contact

Tél : +(33) 1 49 28 46 00