18/10-2021 - Martin Larsen : Human secretory IgA and intestinal microbiota interactions in infancy and adulthood

14 - Octobre - 2021


Bâtiment Kourilsky - 13h–14h

Salle des Conférences (Rez de Chaussée),

184 rue du Faubourg Saint-Antoine, Paris



Human secretory IgA and intestinal microbiota interactions in infancy and adulthood

Martin Larsen

PhD Inserm UMR-S1135 Centre d'Immunologie et des Maladies Infectieuses (CIMI Paris) Invitée par Patrick Soussan (Equipe Chantal Housset) (patrick.soussan@inserm.fr)


Neonate life is a race between microbiota installment through colonization and maturation of host immunity. Indeed, man is colonized immediately upon birth by environmental microbes of primarily maternal origin. Vertical transmission of immunity through breastfeeding allows the child to jump-start the immune maturation process and cope with the massive ongoing microbial invasion. Initial colonization and transfer of maternal immunity through breastfeeding are believed to impact infant health at short- and long-term by conferring protection from infection and potentially resistance to metabolic and allergic diseases. I will discuss how host immunity, in particular microbe-specific secretory IgA, regulates the composition of the gut microbiota in an antigen-specific manner. I will outline mechanisms implicated in this regulation and finally I will present recent data aiming to decipher associations between microbiota, microbiota-specific immunity and host factors such as diet, life style and allergic disease.

Hôpital St-Antoine

Bâtiment Kourilsky
34 rue Crozatier
75012 PARIS

Sorbonne Université
27 rue Chaligny
75012 PARIS

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