12/09-2022 - Laurent DEBARBIEUX : Phage therapy, the lengthy path for bacteriophages to reach the patients
08 - Septembre - 2022
LES LUNDIS DE SAINT-ANTOINE
Bâtiment Kourilsky - 13h–14h
Salle des Conférences (Rez de Chaussée),
184 rue du Faubourg Saint-Antoine, Paris
***
LUNDI 12 SEPTEMBRE 2022
Phage therapy, the lengthy path for bacteriophages to reach the patients
Charles -Antoine DUTERTRE
Directeur de Recherches
invité par Equipe de Harriet CORVOL, (Equipe CORVOL (harriet.corvol@inserm.fr))
***
Antimicrobial resistance is major public health issue because the pipeline of drugs is running dry. Estimation of the number of deaths caused by antibiotic resistant bacteria within the next decades is worrisome. In this context, the interest for using bacteriophages, viruses that recognize, infect and lyse specifically bacteria, is growing supported by experimental data and case reports. During this talk, I’ll highlight the challenges for researchers and clinicians to perform translational research for improving patient’s access to phage therapy. More specifically, I will show how the use of animal models helped us deciphering the parameters involved in the efficacy of treatments in terms of doses and route of administration of bacteriophages (pharmacometry), as well as host response (immune cells) and phage resistance (molecular mechanisms).
Afin d'assister à cette conférence vous pourrez vous connecter sur le lien zoom suivant :
