Research Director CNRS, Chair of the Biophysics Research Axis of the Physics Department of ENS Paris, PI of the Biological Emulsions Team, Ecole Normale Supérieure de Paris
invité par Equipe de Bruno FEVE
(Equipe Bruno FEVE (corinne.vigouroux@inserm.fr))
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Lipid droplets (LDs) play a crucial role in cellular lipid metabolism and possess diverse non-metabolic functions. The assembly of LDs involves multiple steps, starting with the synthesis of neutral lipids in the endoplasmic reticulum (ER). These hydrophobic neutral lipids accumulate within the bilayer membrane's hydrophobic core region. Subsequently, they undergo phase separation and assemble into spherical LDs that bud from the ER membrane. Seipin, along with other factors, catalyzes this phase separation process. Dysfunction of seipin is associated with lipodystrophy and motor neuron diseases. However, the precise mechanism by which seipin participates in phase separation remains an open question. Recent discoveries have suggested that the transmembrane domains of seipin interact favorably with triglycerides. In my presentation, I will discuss our recent advances in understanding LD assembly and provide insights into the role of seipin in the biogenesis of triglyceride and cholesterol ester-rich LDs.
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