11/04-2022 - Cécile LEGALLAIS : LIVER ON CHIP and 3D MODEL

06 - Avril - 2022

LES LUNDIS DE SAINT-ANTOINE

Bâtiment Kourilsky - 13h–14h

Salle des Conférences (Rez de Chaussée),

184 rue du Faubourg Saint-Antoine, Paris

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LUNDI 11 AVRIL 2022

LIVER ON CHIP and 3D MODEL

Cécile LEGALLAIS

Directeur de Recherche CNRS - UMR CNRS 7338 Biomechanics and Bioengineering - Université de Technologie de Compiègne (UTC)

invité par Equipe de Chantal HOUSSET, (Equipe Chantal HOUSSET (chantal.housset@inserm.fr)

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Organ on chip or organoids are promising platform for preclinical studies of new drugs or in predictive toxicology for chemicals. Such alternative methods are promoted to follow the 3R recommendations: reduce, refine, and replace animal trials. Liver spheroids and organoids can also be employed in organ support system and regenerative medecine perspectives. The 3D culture of cells in an adequate environment and under perfusion demonstrated better and prolonged maintenance of cells' functions or differentiation. The design of bioreactors is a key issue to achieve such goals. In this talk, two major applications will be presented : the development of an extracorporeal bioartificial liver, and the studies performed with liver on chip systems for toxicological studies. We have developed at UTC a specific platform where 24 biochips can be positioned in series or in parallel. ADME processes can thus be mimicked in such configuration. We will also comment the potential limits associated with these systems and with data analysis.

Afin d'assister à cette conférence vous pourrez vous connecter sur le lien zoom suivant :

Sujet : Lundi de Saint Antoine

Heure : 11 avr. 2022 12:30 PM Paris

Participer à la réunion Zoom

https://us02web.zoom.us/j/82944673969?pwd=dkhoV3kweGNiUUwyUDhHKzB2NzJOQT09

ID de réunion : 829 4467 3969

Code secret : 526795

Hôpital St-Antoine

Bâtiment Kourilsky
34 rue Crozatier
75012 PARIS

Sorbonne Université
27 rue Chaligny
75012 PARIS

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