Organ on chip or organoids are promising platform for preclinical studies of new drugs or in predictive toxicology for chemicals. Such alternative methods are promoted to follow the 3R recommendations: reduce, refine, and replace animal trials. Liver spheroids and organoids can also be employed in organ support system and regenerative medecine perspectives. The 3D culture of cells in an adequate environment and under perfusion demonstrated better and prolonged maintenance of cells' functions or differentiation. The design of bioreactors is a key issue to achieve such goals. In this talk, two major applications will be presented : the development of an extracorporeal bioartificial liver, and the studies performed with liver on chip systems for toxicological studies. We have developed at UTC a specific platform where 24 biochips can be positioned in series or in parallel. ADME processes can thus be mimicked in such configuration. We will also comment the potential limits associated with these systems and with data analysis.
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