Lundi 08/04-2019 - Charlotte MADORE : Mechanisms of microglia regulation during development and neurodegeneration

08 - Avril - 2019

LES LUNDIS DE SAINT-ANTOINE

Bâtiment Kourilsky - 13h–14h

Salle des Conférences (Rez de Chaussée),

184 rue du Faubourg Saint-Antoine, Paris

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LUNDI 8 AVRIL 2019

Mechanisms of microglia regulation during development and neurodegeneration

Charlotte MADORE

Brigham and Women's Hospital | BWH, Department of Neurology, Boston MA

Invitée par Guillaume Dorothée (guillaume.dorothee@inserm.fr)

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Microglia are the resident macrophages of the central nervous system (CNS). They are activated in response to inflammatory stimuli or trauma, producing pro- and anti-inflammatory factors. In return, these factors modulate neuronal activity which can affect in fine learning and memory abilities. Whereas acute microglia activation can be beneficial, chronic activation can be deleterious for the CNS. Recent work shed light on a key homeostatic role of microglia during brain development showing their ability to promote neuronal network maturation through phagocytic activity. Interestingly, early-life adversities such as nutritional deficiencies, can modulate microglia homeostatic activity potentially predisposing to neurodegenerative diseases later on. In neurodegeneration, microglia play a pivotal role in the maintenance of brain homeostasis but lose progressively their homeostatic functions. They acquire a dysfunctional phenotype which is driven at the transcriptional level by a TREM2-APOE molecular pathway. Understanding how microglia are regulated contributes to identify novel targets that could help the restoration of homeostatic microglia and is crucial to better understand the emergence of neurodegenerative diseases including Alzheimer’s disease.

Centre de Recherche
Saint-Antoine
UMR_S 938

Hôpital St-Antoine

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