08/03-2021 - Robin Ramos : Study of the cytotoxicity and intracellular fate of half-sandwich iridium complexes as potential anticancer drugs

03 - Mars - 2021

LES LUNDIS DE SAINT-ANTOINE

Bâtiment Kourilsky - 13h–14h

Salle des Conférences (Rez de Chaussée),

184 rue du Faubourg Saint-Antoine, Paris

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LUNDI 08 MARS 2021

 Study of the cytotoxicity and intracellular fate of half-sandwich iridium complexes as potential anticancer drugs

Robin Ramos

Doctorant Sciences sous la direction de Joelle Sobczak-Thépot (Equipe Prunier) (joelle.sobczak@inserm.fr)

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Increasing interest is currently focused on novel metallo-drugs, exhibiting promising cytotoxic properties making them potential anticancer drugs. Half-sandwich complexes of iridium (III) are currently investigated but their mechanism of action is still poorly understood at the molecular level. We recently published a series of 10 complexes including phenyloxazoline derivatives as C^N chelating ligands and showed that their cytotoxicity on HeLa cells was at least partly linked to their ability to raise the level of intracellular H2O2.

A convenient strategy to get insights into the mechanism of action of metal-based drugs is to append a fluorescent reporter group so as to track them within cells and analyse their subcellular distribution. To this end, we introduced an iridium complex comprising a modified phenyloxazoline ligand to which was appended a BODIPY entity. BODIPY derivatives are bright, highly photostable fluorophores whose emission properties are generally insensitive to pH changes or polarity. Results of this strategy will be presented.

Centre de Recherche
Saint-Antoine
UMR_S 938

Hôpital St-Antoine

Contact

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