07/02-2022 - Diego GARCIA-WEBER : Sweet innate immunity : Cytokine production upon bacterial ADP-heptose sensing & regulation of endothelial barrier function in an inflammatory context

02 - Février - 2022

LES LUNDIS DE SAINT-ANTOINE

Bâtiment Kourilsky - 13h–14h

Salle des Conférences (Rez de Chaussée),

184 rue du Faubourg Saint-Antoine, Paris

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LUNDI 07 FEVIER 2022

Sweet innate immunity : Cytokine production upon bacterial ADP-heptose sensing & regulation of endothelial barrier function in an inflammatory context

Diego GARCIA-WEBER

MC, Ecole Pratique des Haute Etudes / INSERM UMR_S938 - Laboratoire “Microbiote, Intestin et Inflammation”

Equipe Philippe Seksik et Harry Sokol, (Equipe Philippe Seksik et Harry Sokol) ( harry.sokol@inserm.fr)

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The activation of the inflammatory response is key to clear microbial infections and restore tissue homeostasis. However, when excessive or unrestricted, this phenomenon becomes more harmful tan beneficial and underlies the development of acute and chronic inflammatory pathologies. During this talk, as a newly recruited Assistant Professor at CRSA/EPHE, I will present the work achieved in the field of inflammation and infection during my PhD (CBMSO, Madrid, PI Dr. Jaime Millán, cell biology of inflammation) and my post-doc (Institut Cochin, Paris, PI Dr. Cécile Arrieumerlou, cell signaling during bacterial infections). I will first describe the main publications from my PhD work by presenting different celular mechanisms that regulate endothelial barrier function in an inflammatory context induced by TNF-alpha (Marcos-Ramiro, García-Weber et al., 2016 JCB; García-Weber et al., 2018, CMLS). Second, I will show how the sensing of a newly identified PAMP, the bacterial sugar ADP-heptose, induces cytokine production during intestinal infection by the enteropathogen Shigella flexneri (García-Weber et al., 2018 EMBO Rep). Finally, I will briefly present the main projects in which I will be involved in the “Microbiota, Intestine and Inflammation” team at CRSA.

Afin d'assister à cette conférence vous pourrez vous connecter sur le lien zoom suivant :

Sujet : Lundi de Saint Antoine

Heure : 7 févr. 2022 12:30 PM Paris

Participer à la réunion Zoom https://us02web.zoom.us/j/86153313968?pwd=cFRqZHRwcW5JWHFZTU9mcnp0dWlFdz09

ID de réunion : 861 5331 3968 Code secret : 572683

Hôpital St-Antoine

Bâtiment Kourilsky
34 rue Crozatier
75012 PARIS

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75012 PARIS

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