03/06-2019 - Nadège Bondurand : Control of neural crest development and associated neurocristopathies; SOX10 and A- to I- RNA editing

14 - Mai - 2019

LES LUNDIS DE SAINT-ANTOINE

Bâtiment Kourilsky - 13h–14h

Salle des Conférences (Rez de Chaussée),

184 rue du Faubourg Saint-Antoine, Paris

***

LUNDI 03 JUIN 2019

Control of neural crest development and associated neurocristopathies; SOX10 and A- to I- RNA editing

Alexandre How-Kit

Institut Imagine

Equipe Netchine, invitée par Marie-Laure Sobrier

***

Neural crest cells are a population of multipotent precursor cells that emerge at the borders of the neural tube, migrate extensively throughout the embryo, and differentiate into a variety of cell types including skin pigment cells (melanocytes), neurons and glia of the peripheral and enteric nervous systems. Proper proliferation, survival, migration, and differentiation of these cells require precise coordination and control. Errors in this program lead to various disorders regrouped under the name of neurocristopathies. From 1998 on, our group has investigated the molecular and cellular bases of several of these neural crest-derived disorders, by combining genetics, molecular and developmental biology approaches. Analysis of animal models and human disorders led us to identify several genes considered as major players during neural crest development, including the SOX10 transcription factor. In vivo (mouse models) and in vitro functional analyses helped us decipher the role of this transcription factor mainly in the enteric nervous system as well as the molecular and cellular mechanisms underlying phenotype variability observed. Recently, the role of epigenetic and post-transcriptional modifications was also established. On line with these observations, we highlighted the role of one of these modifications: Adenosine to Inosine RNA editing. Bondurand N, Imagine Institute, team J. Amiel and S. Lyonnet “Embryology and genetics of human malformation"

Centre de Recherche
Saint-Antoine
UMR_S 938

Hôpital St-Antoine

Contact

Tél : +(33) 1 49 28 46 89