01/03-2021 - Enrico Velardi : Identification of strategies to promote immune reconstitution after insults

01 - Mars - 2021


Bâtiment Kourilsky - 13h–14h

Salle des Conférences (Rez de Chaussée),

184 rue du Faubourg Saint-Antoine, Paris


LUNDI 01 MARS 2021

 Identification of strategies to promote immune reconstitution after insults

Enrico Velardi

Laboratory of Immune Regeneration and Experiemental Hematology Department of Pediatric Hematology and Oncology Rome, Italie

Invité par Florent Malard (Equipe Mohty)(florent.malard@inserm.fr)


Allogeneic hematopoietic stem cell transplantation (HCT) is a potentially curative treatment for patients with a variety of hematologic malignancies, such as leukemia, lymphoma, and for some solid tumors. However, the post-transplant immunosuppression associated with the conditioning regimens limits its wider application. Delayed immune reconstitution, especially in the CD4 T cell lineage, is associated with an increased risk of opportunistic infections and malignant relapses, and is widely recognized as one of the most important clinical hurdles for allo-HCT. The primary focus of the research team of Dr. Enrico Velardi at the Bambino Gesù Children's Hospital (Rome) is to understand the mechanisms driving immune reconstitution after insults, with a particular emphasis on the process of thymic regeneration, in order to identify novel therapies to enhance T-cell immunity. Such interventions could be valuable, not only for recipients of HCT, but also for individuals with T cell deficiencies due to aging (immunosenescence), infectious diseases, radio- or chemo-therapy. In this talk, Dr. Velardi will discuss his recent work in this field.

Centre de Recherche
UMR_S 938

Hôpital St-Antoine


Tél : +(33) 1 49 28 46 00